Phenotypes associated with this allele

• Allele Symbol: Foxo3^Gt(XAO26)Byg
• Allele Name: gene trap XAO26, BayGenomics
• Allele ID: MGI:3510105
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Foxo3^Gt(XAO26)Byg/Foxo3^Gt(XAO26)Byg	involves: 129P2/OlaHsd	MGI:3510464

Genotype
MGI:3510464

hm1

• Allelic Composition: Foxo3^Gt(XAO26)Byg/Foxo3^Gt(XAO26)Byg
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

early reproductive senescence ( J:93593 )

• females infertile after 12 weeks of age

endocrine/exocrine glands

salivary gland inflammation ( J:93593 )

abnormal ovarian folliculogenesis ( J:93593 )

♀

hematopoietic system

enlarged spleen ( J:93593 )

• 1.75-2 times larger than wild-type

spleen hyperplasia ( J:93593 )

abnormal T cell physiology ( J:93593 )

abnormal T cell activation ( J:93593 )

• T cell hyperactivity evidenced by increased cytokine production and higher spontaneous NF-kappaB activity

increased T cell proliferation ( J:93593 )

immune system

abnormal T cell physiology ( J:93593 )

abnormal T cell activation ( J:93593 )

• T cell hyperactivity evidenced by increased cytokine production and higher spontaneous NF-kappaB activity

increased T cell proliferation ( J:93593 )

abnormal immune system organ morphology ( J:93593 )

enlarged spleen ( J:93593 )

• 1.75-2 times larger than wild-type

spleen hyperplasia ( J:93593 )

enlarged lymph nodes ( J:93593 )

• 1.75-2 times larger than wild-type

lymphoid hyperplasia ( J:93593 )

increased inflammatory response ( J:93593 )

salivary gland inflammation ( J:93593 )

kidney inflammation ( J:93593 )

lung inflammation ( J:93593 )

renal/urinary system

kidney inflammation ( J:93593 )

reproductive system

abnormal ovarian folliculogenesis ( J:93593 )

♀

early reproductive senescence ( J:93593 )

• females infertile after 12 weeks of age

respiratory system

lung inflammation ( J:93593 )

digestive/alimentary system

salivary gland inflammation ( J:93593 )

cellular

increased T cell proliferation ( J:93593 )

growth/size/body

enlarged spleen ( J:93593 )

• 1.75-2 times larger than wild-type

spleen hyperplasia ( J:93593 )