Phenotypes associated with this allele

• Allele Symbol: Tg(Ela1-TAg*)79Mjt
• Allele Name: transgene insertion 79, Mary J Tevethia
• Allele ID: MGI:3510407
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Ela1-TAg*)79Mjt/0 Tg(MUC1)79.24Gend/0	involves: C57BL/6 * DBA/2	MGI:3777635
tg2	Tg(Ela1-TAg*)79Mjt/0	involves: C57BL/6 * DBA/2	MGI:3777580

Genotype
MGI:3777635

cx1

• Allelic Composition: Tg(Ela1-TAg*)79Mjt/0; Tg(MUC1)79.24Gend/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased pancreas tumor incidence ( J:64570 )

• mice develop pancreatic tumors that can be grossly visualized at 9 weeks of age

• at 18 and 21 weeks, mice develop large solid tumor masses of less differentiated acinar cell carcinomas

increased pancreas adenoma incidence ( J:64570 )

• pancreas consists of acinar cell microadenomas

increased pancreatic acinar cell carcinoma incidence ( J:64570 )

• pancreas consists of acinar cell carcinomas; well-differentiated acinar cell carcinomas are observed

endocrine/exocrine glands

abnormal pancreas morphology ( J:64570 )

• double transgenic mice exhibit acinar cell dysplasia at birth, which progresses to single or multiple cell acinar cell carcinomas

• increased pancreas weight is general indicator of tumor burden, but in many animals 15 weeks of age or older, pancreas weights do not increase presumably due to cachexia

increased pancreas tumor incidence ( J:64570 )

• mice develop pancreatic tumors that can be grossly visualized at 9 weeks of age

• at 18 and 21 weeks, mice develop large solid tumor masses of less differentiated acinar cell carcinomas

increased pancreas adenoma incidence ( J:64570 )

• pancreas consists of acinar cell microadenomas

increased pancreatic acinar cell carcinoma incidence ( J:64570 )

• pancreas consists of acinar cell carcinomas; well-differentiated acinar cell carcinomas are observed

immune system

immune system phenotype ( J:64570 )

N • nonimmunized mice develop anti-MUC1 cytotoxic T lymphocytes by 12 weeks and show 80% lysis of MUC1-expressing target cells by 18 weeks

Genotype
MGI:3777580

tg2

• Allelic Composition: Tg(Ela1-TAg*)79Mjt/0
• Genetic Background: involves: C57BL/6 * DBA/2

mortality/aging

decreased tumor-free survival time ( J:78026 )

• almost all mice develop life-threatening tumors and become moribund between 16 and 31 weeks of age

growth/size/body

distended abdomen ( J:78026 )

• many animals show evidence of abdominal distention from tumor formation

neoplasm

increased pancreas tumor incidence ( J:78026 )

• mice develop single or multiple pancreatic tumors; one large or multiple small tumors are found within or replacing the pancreas

• tumors are soft and gray with multiple red cystic or hemorrhagic foci

increased pancreas adenoma incidence ( J:78026 )

• animals examined between 16 and 26 weeks display acinar cell adenomas and dysplastic acinar cells

increased pancreatic acinar cell carcinoma incidence ( J:78026 )

• pancreas consists of acinar cell carcinoma cells instead of normal tissue in some severe cases

• mice examined at 10 and 16 weeks of age show pancreatic acinar cell carcinomas

increased metastatic potential ( J:78026 )

• in some mice, largest tumors metastasize to liver, and in some cases to the mesenteric lymph nodes or serosa of diaphragm

endocrine/exocrine glands

abnormal pancreas morphology ( J:78026 )

• in larger tumors, foci of necrosis almost completely replaced normal pancreas tissue

• pancreatic tissue between tumors is dense, firm and whiter than normal, containing multiple foci of small hemorrhagic cysts

• normal acinar tissue is absent when pancreas of each tumor-bearing animal is examined

• newborn transgenic mice display lack of normal pancreas tissue and show only dysplastic acinar tissue

increased pancreas tumor incidence ( J:78026 )

• mice develop single or multiple pancreatic tumors; one large or multiple small tumors are found within or replacing the pancreas

• tumors are soft and gray with multiple red cystic or hemorrhagic foci

increased pancreas adenoma incidence ( J:78026 )

• animals examined between 16 and 26 weeks display acinar cell adenomas and dysplastic acinar cells

increased pancreatic acinar cell carcinoma incidence ( J:78026 )

• pancreas consists of acinar cell carcinoma cells instead of normal tissue in some severe cases

• mice examined at 10 and 16 weeks of age show pancreatic acinar cell carcinomas