Phenotypes associated with this allele

• Allele Symbol: Tg(Ela1-TAg*)289Mjt
• Allele Name: transgene insertion 289, Mary J Tevethia
• Allele ID: MGI:3510408
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Ela1-TAg*)289Mjt/0	involves: C57BL/6 * DBA/2	MGI:3777579

Genotype
MGI:3777579

tg1

• Allelic Composition: Tg(Ela1-TAg*)289Mjt/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:78026 )

• mice become moribund around 20-30 weeks of age

growth/size/body

distended abdomen ( J:78026 )

• many mice show clear abdominal distention resulting from tumor growth around 20-30 weeks of age

neoplasm

increased pancreas tumor incidence ( J:78026 )

• mice develop pancreatic tumors between 20.5 and 30.5 weeks of age; tumor histological features are indistinguishable from tumors in Tg(Ela1-Tag*)79Mjt animals

increased pancreas adenoma incidence ( J:78026 )

• transgenic mice show acinar microadenomas as early as 10 weeks of age

increased pancreatic acinar cell carcinoma incidence ( J:78026 )

• acinar cell carcinomas are apparent as early as 10 weeks of age

endocrine/exocrine glands

abnormal pancreas morphology ( J:78026 )

• embryonic pancreas shows dysplasia in transgenic mice

• after birth, pancreatic dysplasia progresses to primary pancreatic acinar cell tumors with 100% penetrance

increased pancreas tumor incidence ( J:78026 )

• mice develop pancreatic tumors between 20.5 and 30.5 weeks of age; tumor histological features are indistinguishable from tumors in Tg(Ela1-Tag*)79Mjt animals

increased pancreas adenoma incidence ( J:78026 )

• transgenic mice show acinar microadenomas as early as 10 weeks of age

increased pancreatic acinar cell carcinoma incidence ( J:78026 )

• acinar cell carcinomas are apparent as early as 10 weeks of age