Phenotypes associated with this allele

• Allele Symbol: Zfp385a^tm1Ber
• Allele Name: targeted mutation 1, Alan Bernstein
• Allele ID: MGI:3510440
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfp385a^tm1Ber/Zfp385a^tm1Ber	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3510699

Genotype
MGI:3510699

hm1

• Allelic Composition: Zfp385a^tm1Ber/Zfp385a^tm1Ber
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:93829 )

• the number of homozygotes decreases after birth especially around 2-3 weeks after birth

cardiovascular system

gastrointestinal hemorrhage ( J:93829 )

• at 4 weeks of age hemorrhage is seen primarily in the brain and gastrointestinal tract

intracranial hemorrhage ( J:93829 )

• at 4 weeks of age hemorrhage is seen primarily in the brain and gastrointestinal tract

digestive/alimentary system

gastrointestinal hemorrhage ( J:93829 )

• at 4 weeks of age hemorrhage is seen primarily in the brain and gastrointestinal tract

growth/size/body

decreased body size ( J:93829 )

• decreased body size is noticeable at 4 weeks of age

hematopoietic system

abnormal megakaryocyte morphology ( J:93829 )

• megakaryocytes have fewer alpha-granules and more vacuoles compared to wild-type suggesting a block in terminal maturation

abnormal platelet morphology ( J:93829 )

• large faint colored platelets are occasionally seen and platelets contain fewer alpha-granules and more vacuoles compared to wild-type

decreased platelet alpha-granule number ( J:93829 )

• platelets contain fewer alpha-granules

nervous system

intracranial hemorrhage ( J:93829 )

• at 4 weeks of age hemorrhage is seen primarily in the brain and gastrointestinal tract

homeostasis/metabolism

abnormal blood coagulation ( J:93829 )

• bleeding times are normal however mutants are more prone to rebleed