Phenotypes associated with this allele

• Allele Symbol: Cpb2^tm1Nok
• Allele Name: targeted mutation 1, Noriko Okada
• Allele ID: MGI:3510646
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cpb2^tm1Nok/Cpb2^tm1Nok	involves: 129P2/OlaHsd * BALB/c	MGI:3510785

Genotype
MGI:3510785

hm1

• Allelic Composition: Cpb2^tm1Nok/Cpb2^tm1Nok
• Genetic Background: involves: 129P2/OlaHsd * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:93733 )

• considerably reduced numbers of homozygotes are born from matings of heterozygotes

immune system

impaired complement alternative pathway ( J:93733 )

• cobra venom factor induced lethal inflammatory reactions in mice previously sensitized with low dose injections of lipopolysaccharide

increased inflammatory response ( J:93733 )

• increased succeptibility to inflammatory reaction mediated by alternative pathway activation of complement usind cobra venom factor

renal/urinary system

parietal capsular epithelium metaplasia ( J:93733 )

• epithelial cells lining the inner surface of Bowman's capsule are frequently cuboidal rather than flattened