Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Ins2-Irs2)13Mfw transgene insertion 13, Morris F White MGI:3510672 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• compound mutants continue to gain excess weight
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| N |
• compound mutants do not develop hyperglycemia
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice survived more than a year after single Irs2 homozygous mice died
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• rod-driven b-wave implicit time is delayed
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• the amplitude of the a-wave is reduced at all flash intensities tested
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• rod-driven b-wave amplitudes are reduced
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• light-adapted responses are reduced
• across stimulus conditions, cone ERGs are reduced on average to 64.9 % of control response, however the implicit time is not changed
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• dark-adapted ERGs are reduced
• across stimulus conditions, rod ERG responses are reduced on average to 34.9% of controls
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• increased proliferation and number of normal-sized beta cells compared to wild-type and single Irs2 homozygous mice
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• expression of Irs2 in beta cells resulted in a persistent compensatory hyperinsulinemia preventing the development of diabetes
• during intraperitoneal glucose challenge, no glucose intolerance was seen unlike in single Irs2 homozygous mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 8 weeks, islet area increased twofold mainly due to increased density of normal-sized islets
• following streptozotocin treatment, beta cell apoptosis was reduced by greatear than 50% compared to wild-type and transgenics did not develop diabetes
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• 2.7-fold increase in pancreatic insulin content, 3-fold increase in insulin secretion during the first 30 min of an intraperitoneal glucose challenge, however glucose homeostasis was normal during the 24 week experiment and mice never developed diabetes
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• 2.7-fold increase in pancreatic insulin content, 3-fold increase in insulin secretion during the first 30 min of an intraperitoneal glucose challenge, however glucose homeostasis was normal during the 24 week experiment and mice never developed diabetes
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• transgenic mice fed a high-fat diet became obese and exhibited an increase in insulin levels but had normal fasting glucose levels and normal glucose tolerance at a young age
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• improved glucose tolerance compared to wild-type on a high fat diet and in older mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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