Analysis Tools
mortality/aging
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• most died before 8 months of age
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immune system
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• double-positive T cells are completely absent
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• there is a strict developmental block in double negative T cells at the transition from the CD44-negative,CD25-positive stage to the CD44-, CD25- negative stage
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• B cell numbers in the spleens and lymph nodes of mice 20 or more weeks old were 3 to 5 X control levels
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• no single-positive cells are found in the thymus
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• no single-positive cells are found in the thymus
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• 20% of B cells in spleen and lymph nodes had the phenotype of antibody producing cells
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• T cell proliferation associated with TH2 type cells
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• gamma-delta T cells in the periphery express cell surface markers indicative of a memory cell phenotype
• 90% of gamma-delta T cells from 20 week old mice express a Vgamma1.1 chain indicating peripheral expansion of this subpopulation
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• numbers of gamma-delta T cells in the periphery increase with age
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• most of the B cells from secondary lymphoid organs of mice at 20 weeks of age have cell surface markers indicative of a hyperactive state
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• increased 500-1000 fold
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• IgG1 levels were increased 500-1000 fold
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• gamma-delta T cells fail to activate when TCR is crosslinked with antibody
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• in vivo activation of thymocytes by anti-CD3epsilon antibody occurs at a much reduced rate
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• thymus hypocellular due to lack of double positive and single positive T cells
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• general architecture of the spleen is preserved
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• more than 90% of mice with enlarged spleens by 20 weeks of age
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• hyperplasia in the white pulp due to enlarged T-dependent zones
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• increased cellularity made up of lymphocytes and plasmocytes
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• more than 90% of mice with enlarged lymph nodes by 20 weeks of age
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• 30% of gamma-delta T cells from the periphery produce IL-4 when activated
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hematopoietic system
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• thymus hypocellular due to lack of double positive and single positive T cells
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• double-positive T cells are completely absent
|
|
• there is a strict developmental block in double negative T cells at the transition from the CD44-negative,CD25-positive stage to the CD44-, CD25- negative stage
|
|
• B cell numbers in the spleens and lymph nodes of mice 20 or more weeks old were 3 to 5 X control levels
|
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• no single-positive cells are found in the thymus
|
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• no single-positive cells are found in the thymus
|
|
• 20% of B cells in spleen and lymph nodes had the phenotype of antibody producing cells
|
|
• T cell proliferation associated with TH2 type cells
|
|
• gamma-delta T cells in the periphery express cell surface markers indicative of a memory cell phenotype
• 90% of gamma-delta T cells from 20 week old mice express a Vgamma1.1 chain indicating peripheral expansion of this subpopulation
|
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• numbers of gamma-delta T cells in the periphery increase with age
|
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• general architecture of the spleen is preserved
|
|
• more than 90% of mice with enlarged spleens by 20 weeks of age
|
|
• hyperplasia in the white pulp due to enlarged T-dependent zones
|
|
• increased cellularity made up of lymphocytes and plasmocytes
|
|
• most of the B cells from secondary lymphoid organs of mice at 20 weeks of age have cell surface markers indicative of a hyperactive state
|
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• increased 500-1000 fold
|
|
• IgG1 levels were increased 500-1000 fold
|
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• gamma-delta T cells fail to activate when TCR is crosslinked with antibody
|
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• in vivo activation of thymocytes by anti-CD3epsilon antibody occurs at a much reduced rate
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endocrine/exocrine glands
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• thymus hypocellular due to lack of double positive and single positive T cells
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• in vivo activation of thymocytes by anti-CD3epsilon antibody occurs at a much reduced rate
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growth/size/body
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• more than 90% of mice with enlarged spleens by 20 weeks of age
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