Phenotypes associated with this allele

• Allele Symbol: Lat^tm3.1Mal
• Allele Name: targeted mutation 3.1, Bernard Malissen
• Allele ID: MGI:3510779
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lat^tm3.1Mal/Lat^tm3.1Mal	involves: 129S2/SvPas	MGI:3691074

Genotype
MGI:3691074

hm1

• Allelic Composition: Lat^tm3.1Mal/Lat^tm3.1Mal
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal thymus cell ratio ( J:94074 )

• thymi contain CD3+ gamma/delta TCR+ cells, in contrast to some published reports

abnormal thymocyte activation ( J:94074 )

• thymocytes are unable to be activated by anti-CD3epsilon antibody treatment

abnormal gamma-delta T cell differentiation ( J:94074 )

• 5.3-fold reduction in numbers found in the thymus

arrested T cell differentiation ( J:94074 )

• there is a strict developmental block in double negative T cells at the transition from the CD44-negative,CD25-positive stage to the CD44-, CD25- negative stage

decreased T cell number ( J:94074 )

• fewer gamma/delta T cells are present compared to wild-type thymi; progeny of these cells are subsequently lost before reaching periphery

decreased double-positive T cell number ( J:94074 )

• double-positive T cells are completely absent

absent CD4-positive, alpha-beta T cells ( J:94074 )

• no single-positive cells are found in the thymus

absent CD8-positive, alpha-beta T cells ( J:94074 )

• no single-positive cells are found in the thymus

absent mature gamma-delta T cells ( J:94074 )

• no gamma-delta T cells are found in the periphery

increased T cell number ( J:94074 )

• abnormal T cell expansion indicates a lymphoproliferative disorder, associated with a Th2-like polarization (increased Il4 expression)

abnormal splenic cell ratio ( J:94074 )

• spleens lack gamma/delta T cells

abnormal lymph node cell ratio ( J:94074 )

• lymph nodes lack gamma/delta T cells

hematopoietic system

abnormal thymus cell ratio ( J:94074 )

• thymi contain CD3+ gamma/delta TCR+ cells, in contrast to some published reports

abnormal thymocyte activation ( J:94074 )

• thymocytes are unable to be activated by anti-CD3epsilon antibody treatment

abnormal gamma-delta T cell differentiation ( J:94074 )

• 5.3-fold reduction in numbers found in the thymus

arrested T cell differentiation ( J:94074 )

• there is a strict developmental block in double negative T cells at the transition from the CD44-negative,CD25-positive stage to the CD44-, CD25- negative stage

decreased T cell number ( J:94074 )

• fewer gamma/delta T cells are present compared to wild-type thymi; progeny of these cells are subsequently lost before reaching periphery

decreased double-positive T cell number ( J:94074 )

• double-positive T cells are completely absent

absent CD4-positive, alpha-beta T cells ( J:94074 )

• no single-positive cells are found in the thymus

absent CD8-positive, alpha-beta T cells ( J:94074 )

• no single-positive cells are found in the thymus

absent mature gamma-delta T cells ( J:94074 )

• no gamma-delta T cells are found in the periphery

increased T cell number ( J:94074 )

• abnormal T cell expansion indicates a lymphoproliferative disorder, associated with a Th2-like polarization (increased Il4 expression)

abnormal splenic cell ratio ( J:94074 )

• spleens lack gamma/delta T cells

endocrine/exocrine glands

abnormal thymus cell ratio ( J:94074 )

• thymi contain CD3+ gamma/delta TCR+ cells, in contrast to some published reports

abnormal thymocyte activation ( J:94074 )

• thymocytes are unable to be activated by anti-CD3epsilon antibody treatment