Phenotypes associated with this allele

• Allele Symbol: Tg(CMV-EGFP,Rnu6-siAbca1)#Wcyy
• Allele Name: transgene insertion, Winston C Y Yu
• Allele ID: MGI:3510918
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(ALB-cre,CMV-rtTA)#Wcyy/0 Tg(CMV-EGFP,Rnu6-siAbca1)#Wcyy/0	involves: ICR	MGI:3510920

Genotype
MGI:3510920

cn1

• Allelic Composition: Tg(ALB-cre,CMV-rtTA)#Wcyy/0; Tg(CMV-EGFP,Rnu6-siAbca1)#Wcyy/0
• Genetic Background: involves: ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating cholesterol level ( J:93624 )

• serum cholesterol is reduced 35-40% 5 days after doxycycline treatment compared to untreated controls

liver/biliary system

hepatic steatosis ( J:93624 )

• lipid accumulation is seen only in the liver after doxycycline treatment

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Tangier disease		DOID:1388	OMIM:205400	J:93624