Phenotypes associated with this allele

• Allele Symbol: Aqp2^tm1.1Ask
• Allele Name: targeted mutation 1.1, A S Verkman
• Allele ID: MGI:3511258
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aqp2^tm1.1Ask/Aqp2^tm1.1Ask	involves: C57BL/6J * FVB/N	MGI:3511455

Genotype
MGI:3511455

hm1

• Allelic Composition: Aqp2^tm1.1Ask/Aqp2^tm1.1Ask
• Genetic Background: involves: C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:94003 )

• mice survive only 8 days after birth

homeostasis/metabolism

increased blood urea nitrogen level ( J:94003 )

• 7 X normal levels

decreased urine osmolality ( J:94003 )

• approximately 200 mOsm as opposed to 400 mOsm in controls

renal/urinary system

decreased urine osmolality ( J:94003 )

• approximately 200 mOsm as opposed to 400 mOsm in controls

abnormal kidney morphology ( J:94003 )

• showed signs of obstructive uropathy

abnormal kidney medulla morphology ( J:94003 )

• some instances in which the medulla was replaced by a large fluid filled cavity

kidney papillary atrophy ( J:94003 )

• papillary atrophy

dilated renal tubule ( J:94003 )