Phenotypes associated with this allele

• Allele Symbol: Cops5^tm1Jka
• Allele Name: targeted mutation 1, Jun-ya Kato
• Allele ID: MGI:3511260
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cops5^tm1Jka/Cops5^tm1Jka	involves: 129S4/SvJae * C57BL/6	MGI:3511280
ht2	Cops5^tm1Jka/Cops5^+	involves: 129S4/SvJae * C57BL/6	MGI:3511282

Genotype
MGI:3511280

hm1

• Allelic Composition: Cops5^tm1Jka/Cops5^tm1Jka
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:93979 )

• embryos survived to the blastocyst stage and died soon after implantation

embryo

absent inner cell mass proliferation ( J:93979 )

• the number of inner mass cells was greatly reduced after 5 days of blastocyst culture, and the cells ceased to proliferate by the 4th day of culture

abnormal trophoblast giant cell proliferation ( J:93979 )

• trophoblast giant cells ceased to proliferate by the 4th day of blastocyst culture

failure to gastrulate ( J:93979 )

embryonic growth arrest ( J:93979 )

• E7.5 embryos were severely growth-retarded and E6.5 embryos exhibited accelerated apoptotic cell death

decreased embryo size ( J:93979 )

• E7.5 embryos were smaller and disorganized and started to be resorbed, E6.5 embryos were slightly smaller and abnormal in shape than wild-type, and E3.5 embryos were normal

inner cell mass degeneration ( J:93979 )

• enhanced nuclear fragmentation was detected after 3 days of culture

growth/size/body

decreased embryo size ( J:93979 )

• E7.5 embryos were smaller and disorganized and started to be resorbed, E6.5 embryos were slightly smaller and abnormal in shape than wild-type, and E3.5 embryos were normal

cellular

absent inner cell mass proliferation ( J:93979 )

• the number of inner mass cells was greatly reduced after 5 days of blastocyst culture, and the cells ceased to proliferate by the 4th day of culture

abnormal trophoblast giant cell proliferation ( J:93979 )

• trophoblast giant cells ceased to proliferate by the 4th day of blastocyst culture

Genotype
MGI:3511282

ht2

• Allelic Composition: Cops5^tm1Jka/Cops5⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

growth/size/body

decreased body size ( J:93979 )

• mice were significantly smaller than wild-type

decreased body weight ( J:93979 )

• body weight was reduced ~15% in the 15th week after birth