All Phenotypes Med1<tm2Jkr> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Med1^tm2Jkr/Med1^tm2Jkr Tg(Alb1-cre)1Dlr/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3511281
cn2	Med1^tm2Jkr/Med1^tm2Jkr A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺	involves: 129P2/OlaHsd * FVB/N	MGI:5911329
cn3	Med1^tm2Jkr/Med1^tm2Jkr Tg(Myh6-cre)2182Mds/0	involves: 129P2/OlaHsd * FVB/N	MGI:5911326

Allelic Composition	Med1^tm2Jkr/Med1^tm2Jkr Tg(Alb1-cre)1Dlr/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Med1^tm2Jkr mutation (0 available); any Med1 mutation (83 available)
Tg(Alb1-cre)1Dlr mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

abnormal hepatocyte morphology ( J:94123 )

• although liver histology was generally normal, hepatocytes were smaller with a larger nuclear volume

• after 2 weeks of treatment with peroxisome proliferators, the expected hypertrophy did not occur except for a few hepatocytes in centrilobular regions

Allelic Composition	Med1^tm2Jkr/Med1^tm2Jkr A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cf^{Tg(Myh6-cre/Esr1*)1Jmk} mutation (5 available); any A1cf mutation (39 available)
Med1^tm2Jkr mutation (0 available); any Med1 mutation (83 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

The Med1^tm2Jkr/Med1^tm2Jkr A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺ mouse heart is flaccid and flabby after tamoxifen induction.

mortality/aging

premature death ( J:243730 )

• mice survive between 13 and 28 days after the first day of tamoxifen injection

cardiovascular system

abnormal heart morphology ( J:243730 )

• hearts appear increasingly flaccid by 14 days after first tamoxifen injection

enlarged heart ( J:243730 )

• mice treated with tamoxifen at 7 weeks of age exhibit an increase in heart size by 14 days after first tamoxifen injection

thin ventricular wall ( J:243730 )

• tamoxifen treated mice show thinning of the ventricular walls

dilated heart ventricle ( J:243730 )

• tamoxifen treated mice show dilatation of the right and left ventricular chambers with thinning of the walls and myocardial cells

cardiac interstitial fibrosis ( J:243730 )

• interstitial myocardial fibrosis in tamoxifen-treated hearts

dilated cardiomyopathy ( J:243730 )

decreased cardiac muscle contractility ( J:243730 )

• tamoxifen-treated mice show diminished heart contractility with ejection fraction only 11% vs. 64% in controls and fractional shortening of 4.77% vs. 33.88% in controls

abnormal heart echocardiography feature ( J:243730 )

• echocardiography indicates increased left ventricular end-diastolic internal dimension, and decreased fractional shortening and ejection fraction in tamoxifen treated mice

congestive heart failure ( J:243730 )

• in tamoxifen treated mice

cellular

cardiac interstitial fibrosis ( J:243730 )

• interstitial myocardial fibrosis in tamoxifen-treated hearts

increased cardiomyocyte apoptosis ( J:243730 )

• tamoxifen-treated hearts show enhanced apoptosis, with the number of apoptotic cardiomyocytes increased about 10-fold

muscle

dilated cardiomyopathy ( J:243730 )

decreased cardiac muscle contractility ( J:243730 )

• tamoxifen-treated mice show diminished heart contractility with ejection fraction only 11% vs. 64% in controls and fractional shortening of 4.77% vs. 33.88% in controls

increased cardiomyocyte apoptosis ( J:243730 )

• tamoxifen-treated hearts show enhanced apoptosis, with the number of apoptotic cardiomyocytes increased about 10-fold

growth/size/body

enlarged heart ( J:243730 )

• mice treated with tamoxifen at 7 weeks of age exhibit an increase in heart size by 14 days after first tamoxifen injection

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
congestive heart failure	DOID:6000		J:243730
dilated cardiomyopathy	DOID:12930	OMIM:PS115200	J:243730

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Heart sections of Med1^tm2Jkr/Med1^tm2Jkr Tg(Myh6-cre)2182Mds/0 heart reveal thinning of ventricular walls and dilation of chambers.

mortality/aging

premature death ( J:243730 )

• nearly 100% of mice die within 10 days post weaning

cardiovascular system

abnormal myocardial fiber morphology ( J:243730 )

• lipid vacuoles of differing sizes are seen in cardiomyocytes

• cardiomyocytes show varying mitochondrial abnormalities, with some mitochondria containing lipid droplets and membranous swirls

decreased myocardial fiber mitochondrial DNA content ( J:243730 )

• mitochondrial DNA content is decreased in hearts

dilated heart atrium ( J:243730 )

enlarged heart ( J:243730 )

• size of the heart increases by 22-29 days of age

thin ventricular wall ( J:243730 )

dilated heart ventricle ( J:243730 )

• dilation of right and left ventricular chambers with thinning of the walls and myocardial cells

cardiac interstitial fibrosis ( J:243730 )

dilated cardiomyopathy ( J:243730 )

• dilated cardiomyopathy with atrial and ventricular dilatation

decreased cardiac muscle contractility ( J:243730 )

• at day 29, contractility of heart is diminished with a fractional shortening of 9.47% compared to 41.08% in controls and ejection fraction of 20.7% compared to 74.27% in controls

abnormal heart echocardiography feature ( J:243730 )

• echocardiography shows increased left ventricular end-diastolic internal dimension, decreased fractional shortening, and decreased ejection fraction

congestive heart failure ( J:243730 )

cellular

decreased myocardial fiber mitochondrial DNA content ( J:243730 )

• mitochondrial DNA content is decreased in hearts

cardiac interstitial fibrosis ( J:243730 )

increased cardiomyocyte apoptosis ( J:243730 )

• increase in apoptosis in hearts, with an increase in the percentage of apoptotic cardiomyocytes

homeostasis/metabolism

cardiac edema ( J:243730 )

• heart weight/body weight ratio is increased but dry heart weight is decreased, suggesting edematous heart

pulmonary edema ( J:243730 )

• lung weight/body weight ratio is increased most likely due to pulmonary edema

muscle

abnormal myocardial fiber morphology ( J:243730 )

• lipid vacuoles of differing sizes are seen in cardiomyocytes

• cardiomyocytes show varying mitochondrial abnormalities, with some mitochondria containing lipid droplets and membranous swirls

decreased myocardial fiber mitochondrial DNA content ( J:243730 )

• mitochondrial DNA content is decreased in hearts

dilated cardiomyopathy ( J:243730 )

• dilated cardiomyopathy with atrial and ventricular dilatation

decreased cardiac muscle contractility ( J:243730 )

• at day 29, contractility of heart is diminished with a fractional shortening of 9.47% compared to 41.08% in controls and ejection fraction of 20.7% compared to 74.27% in controls

increased cardiomyocyte apoptosis ( J:243730 )

• increase in apoptosis in hearts, with an increase in the percentage of apoptotic cardiomyocytes

abnormal Z line morphology ( J:243730 )

• irregularities in Z band pattern

respiratory system

pulmonary edema ( J:243730 )

• lung weight/body weight ratio is increased most likely due to pulmonary edema

growth/size/body

enlarged heart ( J:243730 )

• size of the heart increases by 22-29 days of age

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
congestive heart failure	DOID:6000		J:243730
dilated cardiomyopathy	DOID:12930	OMIM:PS115200	J:243730

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