Phenotypes associated with this allele

• Allele Symbol: Chrna4^tm2Lst
• Allele Name: targeted mutation 2, Henry A Lester
• Allele ID: MGI:3511287
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chrna4^tm2Lst/Chrna4^tm2Lst	involves: 129S1/Sv * C57BL/6	MGI:3511840

Genotype
MGI:3511840

hm1

• Allelic Composition: Chrna4^tm2Lst/Chrna4^tm2Lst
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced behavioral response to nicotine ( J:93873 )

• homozygotes require a 50-fold lower concentration of nicotine to induce conditioned place preference, hyperactivity, hypothermia, and to develop a tolerance to induced-hypothermia

• a similar increase in sensitivity to nicotine is seen in dopaminergic neurons and in ventral midbrain neurons

enhanced conditioned place preference behavior ( J:93873 )