Analysis Tools
reproductive system
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• Background Sensitivity: mice exhibit poor fecundity after introgression onto a C57BL/6 background
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adipose tissue
| N |
• despite the development of dyslipidemia and severe insulin resistance, mice do not develop steatosis or type 2 diabetes
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• mice exhibit hypertrophy and unilocular lipid deposition in mutant brown adipocytes
• however, defects can be prevented by midgestational administration of doxycycline and reverted by a 6 week treatment with doxycycline
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• mice exhibit hypertrophy in mutant brown adipocytes
• however, defects can be prevented by midgestational administration of doxycycline and reverted by a 6 week treatment with doxycycline
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• gonadal fat pads are severely reduced compared to in wild-type mice
• however, defects can be prevented by midgestational administration of doxycycline and reverted by a 6 week treatment with doxycycline
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• mice exhibit 'buffalo humps' comprised of swollen interscapular fat pads due to hypertrophy and unilocular lipid deposition in mutant brown adipocytes
• however, defects can be prevented by midgestational administration of doxycycline and reverted by a 6 week treatment with doxycycline
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• fibrotic white adipose tissue stroma is filled with fragmented lipid droplets and leukocytes
• remaining adipocytes have irregular shapes and range in size from overtly hypertrophic to minuscule cells
• however, defects were prevented by midgestational administration of doxycycline but adipocyte size does not revert following treatment with doxycycline
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• mice lack subcutaneous adipocytes
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• remaining adipocytes have irregular shapes
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• remaining adipocytes range in size from overtly hypertrophic to minuscule cells
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homeostasis/metabolism
| N |
• despite the development of dyslipidemia and severe insulin resistance, mice do not develop steatosis or type 2 diabetes
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• hyperglycemia develops prepuberty then normalizes latter in life with only sporadic and transient hyperglycemia
• however, treatment with doxycycline reverses metabolic anomalies
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• mice exhibit an increase in serum insulin
• however, treatment with doxycycline reverses metabolic anomalies
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• mice exhibit an increase in serum cholesterol with early onset
• however, treatment with doxycycline reverses metabolic anomalies
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• mice exhibit an increase in serum free fatty acids with early onset
• however, treatment with doxycycline reverses metabolic anomalies
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• mice exhibit an increase in serum triglycerides with early onset
• however, treatment with doxycycline reverses metabolic anomalies
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• mice exhibit severe glucose intolerance
• however, treatment with doxycycline reverses metabolic anomalies
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endocrine/exocrine glands
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• mice exhibit pancreas islet cell hyperplasia
• however, treatment with doxycycline reverses metabolic anomalies
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• mice as old as 12 to 18 months exhibit hyperplasia with intact and insulin-laden pancreatic islets with hyperinsulinemia and normoglycemia
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liver/biliary system
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• liver size is increased by 60% to 150% and is accompanied by hepatocyte hypertrophy and vacuolization
• however, lipid droplet accumulation is not observed
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• mice exhibit hepatocyte hypertrophy and vacuolization
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integument
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• mice lack subcutaneous adipocytes
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growth/size/body
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• mice as old as 12 to 18 months exhibit hyperplasia with intact and insulin-laden pancreatic islets with hyperinsulinemia and normoglycemia
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• liver size is increased by 60% to 150% and is accompanied by hepatocyte hypertrophy and vacuolization
• however, lipid droplet accumulation is not observed
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| congenital generalized lipodystrophy type 2 | DOID:0111136 |
OMIM:269700 |
J:125992 | |
| familial partial lipodystrophy | DOID:0050440 |
OMIM:PS151660 |
J:125992 | |
