Phenotypes associated with this allele

• Allele Symbol: Mab21l2^tm1Nao
• Allele Name: targeted mutation 1, Naoki Takahashi
• Allele ID: MGI:3511363
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mab21l2^tm1Nao/Mab21l2^tm1Nao	involves: 129 * C57BL/6	MGI:3512037

Genotype
MGI:3512037

hm1

• Allelic Composition: Mab21l2^tm1Nao/Mab21l2^tm1Nao
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:93910 )

• mutation is lethal by E14.5

pigmentation

abnormal retina pigment epithelium morphology ( J:93910 )

• the retinal pigment epithelium was not formed in E10.5 or E11.5 mutants

cardiovascular system

abnormal heart position or orientation ( J:93910 )

• abnormal heart position due to reduced ventral body wall thickness

vision/eye

absent lens vesicle ( J:93910 )

• absent lens vesicle at E10.5

aphakia ( J:93910 )

• the lens was absent at E11.5

abnormal optic vesicle formation ( J:93910 )

• at E9.5, the optic vesicle in the area in contact with the surface ectoderm was narrower than in heterozygotes and at E10.5, the optic vesicle did not contact the surface ectoderm and lacked a lens vesicle

abnormal retina morphology ( J:93910 )

• at E11.5, mutants exhibited malformation of the rudiment retina

abnormal retina pigment epithelium morphology ( J:93910 )

• the retinal pigment epithelium was not formed in E10.5 or E11.5 mutants

abnormal retina progenitor cell morphology ( J:93910 )

• reduced retinal progenitor cell proliferation in the dorsal side of the optic vesicle at E9.5

growth/size/body

omphalocele ( J:93910 )

• extruded abdominal organs with an umbilical hernia containing part of the liver

abnormal ventral body wall morphology ( J:93910 )

• reduced ventral body wall thickness, with reduced cell numbers at E10.5 and reduced cell proliferation at E11.5, leading to abnormal heart position and extrusion of abdominal organs