Phenotypes associated with this allele

• Allele Symbol: Pdgfrb^tm1Rheu
• Allele Name: targeted mutation 1, Rainer Heuchel
• Allele ID: MGI:3511432
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdgfrb^tm1Rheu/Pdgfrb^tm1Rheu	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3511444

Genotype
MGI:3511444

hm1

• Allelic Composition: Pdgfrb^tm1Rheu/Pdgfrb^tm1Rheu
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased fibroblast apoptosis ( J:93973 )

• mutant MEFs were more resistant to apoptosis than wild-type

abnormal fibroblast migration ( J:93973 )

• in the absence of stimulation, mutant MEFs showed a strong tendency to migrate into a wounded area compared to wild-type MEFs

hematopoietic system

abnormal embryonic hematopoiesis ( J:138069 )

• at E9.5, the number of CD41+ early hematopietic cells in the yolk sac is decreased 36% compared to in wild-type mice

embryo

abnormal embryonic hematopoiesis ( J:138069 )

• at E9.5, the number of CD41+ early hematopietic cells in the yolk sac is decreased 36% compared to in wild-type mice