homeostasis/metabolism
immune system
hematopoietic system
Allele Symbol Allele Name Allele ID |
Fcgrttm1Dcr targeted mutation 1, Derry C Roopenian MGI:3511510 |
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Summary |
5 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• failure of perinatal IgG from mothers to newborns
• levels of maternal IgGs lowered in homozygous pups about 190 fold
• serum half life of IgG1 segnificantly reduced, 1.4 days as opposed to 9 days
• specific IgG memory response to antigen challenge is significantly reduced
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• failure of perinatal IgG from mothers to newborns
• levels of maternal IgGs lowered in homozygous pups about 190 fold
• serum half life of IgG1 segnificantly reduced, 1.4 days as opposed to 9 days
• specific IgG memory response to antigen challenge is significantly reduced
|
|
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice lack albumin protein in their blood
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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• disruption of Fcgrt does not alter the Yaa-induced premature death on this BXSB background, which causes a mean survival of 32 weeks of age in males
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• IgG levels are normalized
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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