About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fcgrttm1Dcr
targeted mutation 1, Derry C Roopenian
MGI:3511510
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fcgrttm1Dcr/Fcgrttm1Dcr B6.129X1-Fcgrttm1Dcr/DcrJ MGI:4441043
hm2
 		Fcgrttm1Dcr/Fcgrttm1Dcr either: 129 or (involves: 129 * C57BL/6) MGI:3511521
cx3
 		Albem12Mvw/Albem12Mvw
Fcgrttm1Dcr/Fcgrttm1Dcr
Tg(FCGRT)32Dcr/Tg(FCGRT)32Dcr 		B6.Cg-Tg(FCGRT)32Dcr Albem12Mvw Fcgrttm1Dcr/MvwJ MGI:5608908
cx4
 		Fcgrttm1Dcr/Fcgrttm1Dcr
X/Yaa 		BXSB.129X1-Fcgrttm1Dcr/Dcr MGI:6094246
cx5
 		Fcgrttm1Dcr/Fcgrttm1Dcr
Tg(CAG-FCGRT)276Dcr/0 		involves: 129X1/SvJ * C57BL/6 * C57BL/6J MGI:4441042


Genotype
MGI:4441043
hm1
Allelic
Composition		 Fcgrttm1Dcr/Fcgrttm1Dcr
Genetic
Background		 B6.129X1-Fcgrttm1Dcr/DcrJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgrttm1Dcr mutation (23 available); any Fcgrt mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism

immune system

hematopoietic system




Genotype
MGI:3511521
hm2
Allelic
Composition		 Fcgrttm1Dcr/Fcgrttm1Dcr
Genetic
Background		 either: 129 or (involves: 129 * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgrttm1Dcr mutation (23 available); any Fcgrt mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgG level ( J:94189 )
• failure of perinatal IgG from mothers to newborns
• levels of maternal IgGs lowered in homozygous pups about 190 fold
• serum half life of IgG1 segnificantly reduced, 1.4 days as opposed to 9 days
• specific IgG memory response to antigen challenge is significantly reduced

hematopoietic system
decreased IgG level ( J:94189 )
• failure of perinatal IgG from mothers to newborns
• levels of maternal IgGs lowered in homozygous pups about 190 fold
• serum half life of IgG1 segnificantly reduced, 1.4 days as opposed to 9 days
• specific IgG memory response to antigen challenge is significantly reduced




Genotype
MGI:5608908
cx3
Allelic
Composition		 Albem12Mvw/Albem12Mvw
Fcgrttm1Dcr/Fcgrttm1Dcr
Tg(FCGRT)32Dcr/Tg(FCGRT)32Dcr
Genetic
Background		 B6.Cg-Tg(FCGRT)32Dcr Albem12Mvw Fcgrttm1Dcr/MvwJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Albem12Mvw mutation (3 available); any Alb mutation (97 available)
Fcgrttm1Dcr mutation (23 available); any Fcgrt mutation (61 available)
Tg(FCGRT)32Dcr mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating serum albumin level ( J:101977 )
• mice lack albumin protein in their blood




Genotype
MGI:6094246
cx4
Allelic
Composition		 Fcgrttm1Dcr/Fcgrttm1Dcr
X/Yaa
Genetic
Background		 BXSB.129X1-Fcgrttm1Dcr/Dcr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgrttm1Dcr mutation (23 available); any Fcgrt mutation (61 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:179430 )
• disruption of Fcgrt does not alter the Yaa-induced premature death on this BXSB background, which causes a mean survival of 32 weeks of age in males




Genotype
MGI:4441042
cx5
Allelic
Composition		 Fcgrttm1Dcr/Fcgrttm1Dcr
Tg(CAG-FCGRT)276Dcr/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgrttm1Dcr mutation (23 available); any Fcgrt mutation (61 available)
Tg(CAG-FCGRT)276Dcr mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism

immune system
immune system phenotype ( J:110885 )
N
• IgG levels are normalized




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory