Phenotypes associated with this allele

• Allele Symbol: Chd7^Flo
• Allele Name: flouncer
• Allele ID: MGI:3511552
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Chd7^Flo/Chd7^+	C3HeB/FeJ-Chd7^Flo	MGI:3511743
ht2	Chd7^Flo/Chd7^+	involves: C3HeB/FeJ	MGI:3616772

Genotype
MGI:3511743

ht1

• Allelic Composition: Chd7^Flo/Chd7⁺
• Genetic Background: C3HeB/FeJ-Chd7^Flo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal motor coordination/balance ( J:93173 )

impaired righting response ( J:93173 )

• mutants showed a delay in resuming upright position

abnormal placing response ( J:93173 )

• when picked up by the tail and lowered toward a surface, mutants had an abnormal reaching response consisting of curling toward the abdomen

impaired swimming ( J:93173 )

abnormal stationary movement ( J:93173 )

head bobbing ( J:93173 )

circling ( J:93173 )

• mutants circled on average 70 times in 10 min compared to 0 times in wild-type without apparent deafness

hearing/vestibular/ear

abnormal round window morphology ( J:93173 )

• various degrees of abnormalities (from small to completely obliterated) of the round window

abnormal stapes morphology ( J:93173 )

• mutants exhibited a more square-shaped stapes than wild-type mice

abnormal stapes footplate morphology ( J:93173 )

• mutants exhibited a smaller stapes footplate than wild-type mice

increased cochlear outer hair cell number ( J:93173 )

• 2 out of 6 adult mutants had four rows of outer hair cells at the extreme apex of the cochlea and P1 mutants showed larger numbers of outer hair cells in the apical region

abnormal lateral semicircular canal morphology ( J:93173 )

• various degrees of abnormality, ranging from constriction of the canal to complete truncation

skeleton

abnormal round window morphology ( J:93173 )

• various degrees of abnormalities (from small to completely obliterated) of the round window

abnormal stapes morphology ( J:93173 )

• mutants exhibited a more square-shaped stapes than wild-type mice

abnormal stapes footplate morphology ( J:93173 )

• mutants exhibited a smaller stapes footplate than wild-type mice

nervous system

increased cochlear outer hair cell number ( J:93173 )

• 2 out of 6 adult mutants had four rows of outer hair cells at the extreme apex of the cochlea and P1 mutants showed larger numbers of outer hair cells in the apical region

craniofacial

abnormal round window morphology ( J:93173 )

• various degrees of abnormalities (from small to completely obliterated) of the round window

abnormal stapes morphology ( J:93173 )

• mutants exhibited a more square-shaped stapes than wild-type mice

abnormal stapes footplate morphology ( J:93173 )

• mutants exhibited a smaller stapes footplate than wild-type mice

Genotype
MGI:3616772

ht2

• Allelic Composition: Chd7^Flo/Chd7⁺
• Genetic Background: involves: C3HeB/FeJ

mortality/aging

postnatal lethality ( J:104123 )

• after mating to wild-type mice only 32% of pups at weaning are heterozygous

reproductive system

abnormal external female genitalia morphology ( J:104123 )

♀ • females have vulva abnormalities

clitoris hypoplasia ( J:104123 )

♀ • most females have clitoral hypoplasia

vision/eye

keratoconjunctivitis sicca ( J:104123 )

• about 50% of mice have symptoms of keratoconjunctivitis sicca due to dry eyes

dry eyes ( J:104123 )

immune system

keratoconjunctivitis sicca ( J:104123 )

• about 50% of mice have symptoms of keratoconjunctivitis sicca due to dry eyes