Phenotypes associated with this allele

• Allele Symbol: Rps6kb1^tm1Nte
• Allele Name: targeted mutation 1, Naohiro Terada
• Allele ID: MGI:3511860
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rps6kb1^tm1Nte/Rps6kb1^tm1Nte	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4868416
cx2	Eprs1^tm2.1Xen/Eprs1^tm2.1Xen Rps6kb1^tm1Nte/Rps6kb1^tm1Nte	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:6157359

Genotype
MGI:4868416

hm1

• Allelic Composition: Rps6kb1^tm1Nte/Rps6kb1^tm1Nte
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased epididymal fat pad weight ( J:244749 )

decreased inguinal fat pad weight ( J:244749 )

decreased mesenteric fat pad weight ( J:244749 )

decreased retroperitoneal fat pad weight ( J:244749 )

decreased interscapular fat pad weight ( J:244749 )

growth/size/body

decreased body size ( J:155912 , J:244749 )

• smaller in size but otherwise viable and fertile (J:155912)

homeostasis/metabolism

increased carbon dioxide production ( J:244749 )

• in the light and dark phases

increased oxygen consumption ( J:244749 )

• in the light and dark phases

muscle

abnormal tibialis anterior morphology ( J:155912 )

• reduced TA myofiber size

decreased skeletal muscle weight ( J:155912 )

• reduced limb muscle weight

abnormal muscle regeneration ( J:155912 )

• the initial formation of regenerating myofibers is similar to controls

• regenerating mutant myofibers appeared to be arrested at a size significantly smaller than that of the uninjured myofibers, suggesting impairment in the growth of regenerating myofibers

mortality/aging

extended life span ( J:244749 )

• average lifespan is 170 (a 22% increase compared with wild-type)

limbs/digits/tail

abnormal tibialis anterior morphology ( J:155912 )

• reduced TA myofiber size

Genotype
MGI:6157359

cx2

• Allelic Composition: Eprs1^tm2.1Xen/Eprs1^tm2.1Xen; Rps6kb1^tm1Nte/Rps6kb1^tm1Nte
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

adipose tissue

decreased epididymal fat pad weight ( J:244749 )

• not as much as in Rps6kb1^tm1Nte homogygotes

decreased inguinal fat pad weight ( J:244749 )

• not as much as in Rps6kb1^tm1Nte homogygotes

decreased mesenteric fat pad weight ( J:244749 )

• not as much as in Rps6kb1^tm1Nte homogygotes

decreased retroperitoneal fat pad weight ( J:244749 )

• not as much as in Rps6kb1^tm1Nte homogygotes

decreased interscapular fat pad weight ( J:244749 )

• not as much as in Rps6kb1^tm1Nte homogygotes

growth/size/body

decreased body size ( J:244749 )

• not as much as in Rps6kb1^tm1Nte homogygotes