All Phenotypes Aldh1a3<tm1Gdu> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aldh1a3^tm1Gdu/Aldh1a3^tm1Gdu	involves: C57BL/6	MGI:3718028
hm2	Aldh1a3^tm1Gdu/Aldh1a3^tm1Gdu	involves: C57BL/6 * Swiss Webster	MGI:4431235
cx3	Aldh1a2^tm1Gdu/Aldh1a2^tm1Gdu Aldh1a3^tm1Gdu/Aldh1a3^tm1Gdu	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3718031
cx4	Aldh1a1^tm1Gdu/Aldh1a1^tm1Gdu Aldh1a3^tm1Gdu/Aldh1a3^tm1Gdu	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3718029
cx5	Aldh1a1^tm1Gdu/Aldh1a1^tm1Gdu Aldh1a2^tm1Gdu/Aldh1a2^tm1Gdu Aldh1a3^tm1Gdu/Aldh1a3^tm1Gdu	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3718030
cx6	Aldh1a2^tm1Gdu/Aldh1a2^tm1Gdu Aldh1a3^tm1Gdu/Aldh1a3^tm1Gdu	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * Swiss Webster	MGI:4431236
cx7	Aldh1a3^tm1Gdu/Aldh1a3⁺ Chd7^{Gt(S20-7E1)Sor}/Chd7⁺	involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6J	MGI:7506322
cx8	Aldh1a3^tm1Gdu/Aldh1a3^tm1Gdu Chd7^{Gt(S20-7E1)Sor}/Chd7⁺	involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6J	MGI:7506323

Allelic Composition	Aldh1a3^tm1Gdu/Aldh1a3^tm1Gdu
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldh1a3^tm1Gdu mutation (1 available); any Aldh1a3 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:119190 )

• die just after birth

vision/eye

increased total retina thickness ( J:108515 )

• excessive thickening of the neural retina at E14.5

abnormal vitreous body morphology ( J:108515 )

• absent at E14.5

persistent hyperplastic primary vitreous ( J:108515 )

• at E14.5 a prominent retrolenticular membrane is present

Allelic Composition	Aldh1a3^tm1Gdu/Aldh1a3^tm1Gdu
Genetic Background	involves: C57BL/6 * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldh1a3^tm1Gdu mutation (1 available); any Aldh1a3 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:157254 )

N	• apparently normal kidney development

Allelic Composition	Aldh1a2^tm1Gdu/Aldh1a2^tm1Gdu Aldh1a3^tm1Gdu/Aldh1a3^tm1Gdu
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldh1a2^tm1Gdu mutation (1 available); any Aldh1a2 mutation (38 available)
Aldh1a3^tm1Gdu mutation (1 available); any Aldh1a3 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal optic cup morphology ( J:108515 )

• failure of ventral invagination of the optic vesicle at the point that defines the junction of the ventral retina and optic stalk is seen at E10.5 and E11.5 following maternal dietary retinoic acid treatment ending at E8.5

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased periocular mesenchyme apoptosis ( J:108515 )

• at E11.5 almost no apoptotic cells are found in the dorsal and ventral regions of the periocular mesenchyme, unlike in wild-type mice

vision/eye

abnormal periocular mesenchyme morphology ( J:108515 )

• at E11.5 almost no apoptotic cells are found in the dorsal and ventral regions of the periocular mesenchyme, unlike in wild-type mice

• excessive invasion of the periocular mesenchyme into the anterior retina at E14.5

• maternal dietary retinoic acid treatment from E8.5 - E14.5 restores periocular mesenchyme growth to nearly normal

decreased periocular mesenchyme apoptosis ( J:108515 )

• at E11.5 almost no apoptotic cells are found in the dorsal and ventral regions of the periocular mesenchyme, unlike in wild-type mice

increased cornea stroma thickness ( J:108515 )

• thickened at E14.5

thick eyelids ( J:108515 )

• thickened folds at E14.5

abnormal posterior eye segment morphology ( J:108515 )

increased total retina thickness ( J:108515 )

• excessive thickening of the neural retina at E14.5

• maternal dietary retinoic acid treatment from E8.5 - E14.5 restores neural retina thickness to nearly normal

abnormal vitreous body morphology ( J:108515 )

• absent at E14.5

• maternal dietary retinoic acid treatment from E8.5 - E14.5 restores vitreous body development

persistent hyperplastic primary vitreous ( J:108515 )

• at E14.5, a prominent retrolenticular membrane is present

embryo

abnormal periocular mesenchyme morphology ( J:108515 )

• at E11.5 almost no apoptotic cells are found in the dorsal and ventral regions of the periocular mesenchyme, unlike in wild-type mice

• excessive invasion of the periocular mesenchyme into the anterior retina at E14.5

• maternal dietary retinoic acid treatment from E8.5 - E14.5 restores periocular mesenchyme growth to nearly normal

decreased periocular mesenchyme apoptosis ( J:108515 )

• at E11.5 almost no apoptotic cells are found in the dorsal and ventral regions of the periocular mesenchyme, unlike in wild-type mice

growth/size/body

abnormal periocular mesenchyme morphology ( J:108515 )

• at E11.5 almost no apoptotic cells are found in the dorsal and ventral regions of the periocular mesenchyme, unlike in wild-type mice

• excessive invasion of the periocular mesenchyme into the anterior retina at E14.5

• maternal dietary retinoic acid treatment from E8.5 - E14.5 restores periocular mesenchyme growth to nearly normal

decreased periocular mesenchyme apoptosis ( J:108515 )

• at E11.5 almost no apoptotic cells are found in the dorsal and ventral regions of the periocular mesenchyme, unlike in wild-type mice

Allelic Composition	Aldh1a1^tm1Gdu/Aldh1a1^tm1Gdu Aldh1a2^tm1Gdu/Aldh1a2^tm1Gdu Aldh1a3^tm1Gdu/Aldh1a3^tm1Gdu
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldh1a1^tm1Gdu mutation (1 available); any Aldh1a1 mutation (39 available)
Aldh1a2^tm1Gdu mutation (1 available); any Aldh1a2 mutation (38 available)
Aldh1a3^tm1Gdu mutation (1 available); any Aldh1a3 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal optic cup morphology ( J:108515 )

• at E10.5 the ventral optic vesicle has not invaginated to form a complete optic cup following maternal dietary retinoic acid treatment ending at E8.5

• however, dorsal invagination does occur

Allelic Composition	Aldh1a2^tm1Gdu/Aldh1a2^tm1Gdu Aldh1a3^tm1Gdu/Aldh1a3^tm1Gdu
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * Swiss Webster

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal hypoplasia ( J:157254 )

• greatly reduced in size compared with homozygous Aldh1a2^tm1Gdu mice at E14

impaired branching involved in ureteric bud morphogenesis ( J:157254 )

• contain few ureteric bud branches or developing nephrons at E14

Allelic Composition	Aldh1a3^tm1Gdu/Aldh1a3⁺ Chd7^{Gt(S20-7E1)Sor}/Chd7⁺
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldh1a3^tm1Gdu mutation (1 available); any Aldh1a3 mutation (26 available)
Chd7^{Gt(S20-7E1)Sor} mutation (1 available); any Chd7 mutation (138 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal semicircular canal morphology ( J:314662 )

• semicircular abnormalities at E14.5 similar to mice heterozygous for the Chd7 mutation alone

Allelic Composition	Aldh1a3^tm1Gdu/Aldh1a3^tm1Gdu Chd7^{Gt(S20-7E1)Sor}/Chd7⁺
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal semicircular canal morphology ( J:314662 )

• reduced penetrance of semicircular canal abnormalities compared to mice heterozygous for the Chd7 mutation alone

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