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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nrp1tm1Ddg
targeted mutation 1, David D Ginty
MGI:3512099
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nrp1tm1Ddg/Nrp1tm1Ddg involves: 129P2/OlaHsd MGI:4462170
hm2
 		Nrp1tm1Ddg/Nrp1tm1Ddg involves: 129P2/OlaHsd * C57BL/6 MGI:3512115
cx3
 		Nrp1tm1Ddg/Nrp1tm1Ddg
Nrp2tm1Ddg/Nrp2tm1Ddg 		involves: 129P2/OlaHsd MGI:3528190
cx4
 		Nrp1tm1Ddg/Nrp1tm1Ddg
Tg(Thy1-YFP)16Jrs/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3512124
cx5
 		Nrp1tm1Ddg/Nrp1tm1Ddg
Nrp2tm1Ddg/Nrp2tm1Ddg 		involves: 129P2/OlaHsd * C57BL/6 MGI:3512128


Genotype
MGI:4462170
hm1
Allelic
Composition		 Nrp1tm1Ddg/Nrp1tm1Ddg
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp1tm1Ddg mutation (2 available); any Nrp1 mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell physiology ( J:161856 )
• defective T-cell priming by antigen
abnormal dendritic cell physiology ( J:161856 )
• impaired dendritic cell migration

vision/eye
vision/eye phenotype ( J:172268 )
N
• mice exhibit normal retinal stratification

hematopoietic system
abnormal T cell physiology ( J:161856 )
• defective T-cell priming by antigen




Genotype
MGI:3512115
hm2
Allelic
Composition		 Nrp1tm1Ddg/Nrp1tm1Ddg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp1tm1Ddg mutation (2 available); any Nrp1 mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality ( J:93799 )
• 40% die by P7

cardiovascular system
dilated heart atrium ( J:93799 )
• exhibited bilateral atrial enlargement, however no vascular branching defects were observed

growth/size/body
postnatal growth retardation ( J:93799 )
• 70% of P7 survivors are growth retarded

nervous system
abnormal axon guidance ( J:93799 )
• guidance of ophthalmic nerve axons and cutaneous sensory neurons was abnormal so that projections extended beyond their normal zones
abnormal corpus callosum morphology ( J:93799 )
• callosal axons displayed varying degrees of defasciculation with agenesis of corpus callosum resulting in the formation of Probst bundles in extreme cases
abnormal hippocampus morphology ( J:93799 )
• entorhinohippocampal axons were no longer restricted in the stratum lacunosum-moleculare of the ipsilateral hippocampus with many fibers innervating ectopic layers
abnormal trigeminal nerve morphology ( J:93799 )
• defasciculated and abnormally extended ophthalmic branch of the trigeminal nerve, however defects were less severe than in Nrp1tm2.1Ddg
abnormal vestibulocochlear nerve morphology ( J:93799 )
• E12.5 mutants have additional smaller fiber bundles that extend beyond their normal termination zones within the sensory end organs with projection defects persisting at E14.5 and E15.5
abnormal dorsal root ganglion morphology ( J:93799 )
• many cutaneous afferent axons entered the gray matter a E14.5 with some projections extending into the most ventral regions of the spinal cord
• at P2, some axons were outside their normal termination zones, along the midline and in the medial-ventral spinal cord
abnormal spinal nerve morphology ( J:93799 )
• disorganized peripheral projections of spinal nerves in E11.5 mutants

cellular
abnormal axon guidance ( J:93799 )
• guidance of ophthalmic nerve axons and cutaneous sensory neurons was abnormal so that projections extended beyond their normal zones




Genotype
MGI:3528190
cx3
Allelic
Composition		 Nrp1tm1Ddg/Nrp1tm1Ddg
Nrp2tm1Ddg/Nrp2tm1Ddg
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp1tm1Ddg mutation (2 available); any Nrp1 mutation (84 available)
Nrp2tm1Ddg mutation (0 available); any Nrp2 mutation (89 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
persistent truncus arteriosus ( J:95697 )
• persistent truncus arteriosis is seen; however, somitic vasculature is normal




Genotype
MGI:3512124
cx4
Allelic
Composition		 Nrp1tm1Ddg/Nrp1tm1Ddg
Tg(Thy1-YFP)16Jrs/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp1tm1Ddg mutation (2 available); any Nrp1 mutation (84 available)
Tg(Thy1-YFP)16Jrs mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebral cortex pyramidal cell morphology ( J:93799 )
• basal dendrites of layer 5 cortical neurons within the neocortex were markedly diminished in length and complexity




Genotype
MGI:3512128
cx5
Allelic
Composition		 Nrp1tm1Ddg/Nrp1tm1Ddg
Nrp2tm1Ddg/Nrp2tm1Ddg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp1tm1Ddg mutation (2 available); any Nrp1 mutation (84 available)
Nrp2tm1Ddg mutation (0 available); any Nrp2 mutation (89 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
persistent truncus arteriosus ( J:93799 )
• 66% of mutants exhibited truncus arteriosis compared to none in either single homozygous mutants
increased heart atrium size ( J:93799 )
• exhibited bilateral atrial enlargement




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory