Phenotypes associated with this allele

• Allele Symbol: Cort^tm1Ldl
• Allele Name: targeted mutation 1, Luis de Lecea
• Allele ID: MGI:3512113
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cort^tm1Ldl/Cort^tm1Ldl	involves: C57BL/6J	MGI:5302385

Genotype
MGI:5302385

hm1

• Allelic Composition: Cort^tm1Ldl/Cort^tm1Ldl
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:179095 )

• in male, but not female, mice

increased circulating ghrelin level ( J:179095 )

• female mice exhibit increased plasma total and acylated ghrelin levels compared with wild-type mice

increased circulating growth hormone level ( J:179095 )

• in female and male mice

insulin resistance ( J:179095 )

• in male, but not female, mice

increased adrenocorticotropin level ( J:179095 )

• adrenocorticotropin release from primary pituitary cell cultures is increased compared to in wild-type cells

increased circulating adrenocorticotropin level ( J:179095 )

• in female mice

decreased prolactin level ( J:179095 )

• prolactin release from primary pituitary cell cultures is decreased compared to in wild-type cells

decreased circulating prolactin level ( J:179095 )

• in female and male mice

abnormal somatostatin level ( J:179095 )

• male mice exhibit reduced plasma somatostatin levels compared with wild-type mice

behavior/neurological

abnormal maternal nurturing ( J:179095 )

♀ • fewer female mice successfully card for their first litter until weaning compared with wild-type mice

♀ • however, maternal care of second litters is normal

growth/size/body

growth/size/body region phenotype ( J:179095 )

N • mice exhibit normal body weight

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:179095 )

N • mice exhibit normal numbers of somatotrophs, lactotrophs, corticotrophs, thyrotropes, and gonadotrophs