All Phenotypes Timp1<tm1Pds> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Timp1^tm1Pds/Timp1^tm1Pds	involves: 129S4/SvJae	MGI:3033578
hm2	Timp1^tm1Pds/Timp1^tm1Pds	involves: 129S4/SvJae * C57BL/6	MGI:3664802
hm3	Timp1^tm1Pds/Timp1^tm1Pds	involves: C57BL/6	MGI:3525486
cx4	Mmp2^tm1Ito/Mmp2^tm1Ito Timp1^tm1Pds/Timp1^tm1Pds	either: (involves: 129S4/SvJae) or (involves: C57BL/6)	MGI:3525497
cx5	Mmp12^tm1Sds/Mmp12^tm1Sds Timp1^tm1Pds/Timp1^tm1Pds	either: (involves: 129S4/SvJae) or (involves: C57BL/6)	MGI:3525499
cx6	Apoe^tm1Unc/Apoe^tm1Unc Timp1^tm1Pds/Y	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:3652791
cx7	Mmp7^tm1Lmm/Mmp7^tm1Lmm Timp1^tm1Pds/Timp1^tm1Pds	involves: 129S4/SvJae	MGI:3525491
cx8	Mmp9^tm1Tvu/Mmp9^tm1Tvu Timp1^tm1Pds/Timp1^tm1Pds	involves: 129S4/SvJae * 129S6/SvEvTac	MGI:3525489
cx9	Mmp3^tm1Mrl/Mmp3^tm1Mrl Timp1^tm1Pds/Timp1^tm1Pds	involves: C57BL/6	MGI:3525494
ot10	Timp1^tm1Pds/Y	involves: 129S4/SvJae	MGI:3033580
ot11	Timp1^tm1Pds/Y	involves: 129S4/SvJae * C57BL/6	MGI:5576513

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:43744 )

N	• indistinguishable from wild-type controls in metastasis assays

growth/size/body

growth/size/body region phenotype ( J:40265 )

N	• body weight equivalent to control mice at same age

reproductive system

reproductive system phenotype ( J:40265 )

N	• histologically normal ovaries • number of healthy and atretic follicles equivalent to those in control mice • serum estradiol concentrations equivalent to control mice • ovary weight equivalent to control mice

abnormal endometrial gland development ( J:96729 )

• exhibit a significantly greater number of endometrial glands at P15 and P20; however, by P25, the number of glands is similar to wild-type, indicating accelerated endometrial gland formation

abnormal uterus development ( J:96729 )

• accelerated endometrial gland formation during early postnatal uterine development

increased uterus weight ( J:64154 , J:96729 )

• mice that displayed normal estrus had uteri weighing significantly more than wild-type controls during estrus (J:64154)

• exhibit an increase in uterine wet weight at P5, P10 and P25 (J:96729)

abnormal estrus ( J:64154 )

• decreased length of estrus period or failure to display estrus

absent estrus ( J:64154 )

short estrus ( J:64154 )

prolonged proestrus ( J:64154 )

• longer periods of proestrus

absent estrous cycle ( J:64154 )

• less than 50% exhibited normal estrus cycle

reduced female fertility ( J:73618 )

• ~50% achieved pregnancy vs. 78% in wild-type controls

• those that did become pregnant produced fewer litters over a 12-month period than wild-type controls

decreased litter size ( J:73618 )

• when litters were produced, fewer pups per litter were born

cardiovascular system

aortic aneurysm ( J:101938 , J:102182 )

• homozygotes form significantly larger aneurysms than wild-type after elastase infusion to induce aneurysm formation (to model abdominal aortic aneurysm) (J:101938)

• homozygotes, unlike wild-type, also develop aneurysms following saline injection (J:101938)

• homozygotes show increased and continued progression of aneurysm formation compared with wild-type in a thoracic aortic aneurysm model (induced by calcium chloride treatment) (J:102182)

increased left ventricle diastolic pressure ( J:60524 )

• increased left ventricle end-diastolic pressure and volume vs. wild-type controls

abnormal response to cardiac infarction ( J:95572 )

• exhibit accelerated myocardial remodeling after myocardial infarction (coronary ligation) as indicated by increased left ventricular (LV) dilatation and LV dysfunction the accelerated remodeling can be rescued by MMP inhibition

immune system

decreased susceptibility to bacterial infection ( J:94836 )

• bacterial clearance following corneal infection is increased with 2 to 3 orders of magnitude fewer viable bacteria being found in mutant eyes 24 - 48 hours after infection

hematopoietic system

hematopoietic system phenotype ( J:100411 )

N	• normal blood cell counts and subtype distribution

decreased bone marrow cell number ( J:100411 )

• bone marrow cellularity is decreased by approximately 50% without changes in subtype composition

homeostasis/metabolism

abnormal response to cardiac infarction ( J:95572 )

increased circulating estradiol level ( J:64154 )

• during estrus and diestrus

decreased circulating progesterone level ( J:64154 )

• during estrus only

endocrine/exocrine glands

abnormal endometrial gland development ( J:96729 )

• exhibit a significantly greater number of endometrial glands at P15 and P20; however, by P25, the number of glands is similar to wild-type, indicating accelerated endometrial gland formation

Allelic Composition	Timp1^tm1Pds/Timp1^tm1Pds
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Timp1^tm1Pds mutation (1 available); any Timp1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:112941 )

• mutants show 76% survival rate 30 days after bleomycin treatment vs 100% in wild-type

growth/size/body

weight loss ( J:112941 )

• mutants show 33.3% weight reduction 7 days after bleomycin treatment vs 26.6% decrease observed in treated wild-type

respiratory system

respiratory system phenotype ( J:112941 )

N	• fibrotic response to lung injury is similar in mutants and wild-type; Timp1-deficiency does not alter collagen accumulation • neutrophil chemotactic activity is not different from wild-type, following bleomycin treatment

lung hemorrhage ( J:112941 )

• at day 7, bleomycin-treated mutants show 3-fold higher concentrations of erythrocytes in BAL vs wild-type; number of erythrocytes per unit area of lung is >4-fold higher vs wild-type at day 7

lung inflammation ( J:112941 )

• tissue sections show extensive neutrophil accumulation at day7 after bleomycin treatment vs wild-type

hematopoietic system

increased neutrophil cell number ( J:112941 )

• percentage and concentration are 2-fold higher compared to wild-type by day 3 following treatment, and at day 7, concentration is 3.5-fold higher and percentage is 1.5 time higher compared to controls

• at day 7 after treatment, BAL neutrophil percentage and concentration are 3- and 10-fold higher in Timp1-null mice compared to Timp2-null animals; values for Timp2-null mice are similar to wild-type

• concentrations of alveolar macrophages or lymphocytes recovered from treated mutants are similar to those in treated wild-type

immune system

increased neutrophil cell number ( J:112941 )

• concentrations of alveolar macrophages or lymphocytes recovered from treated mutants are similar to those in treated wild-type

lung inflammation ( J:112941 )

• tissue sections show extensive neutrophil accumulation at day7 after bleomycin treatment vs wild-type

cardiovascular system

lung hemorrhage ( J:112941 )

• at day 7, bleomycin-treated mutants show 3-fold higher concentrations of erythrocytes in BAL vs wild-type; number of erythrocytes per unit area of lung is >4-fold higher vs wild-type at day 7

increased vascular permeability ( J:112941 )

• pulmonary vaculature in bleomycin-treated mice shows greater leakage than similarly treated wild-type animals

• mice exposed to bleomycin display a large increase in albumin and IgM in bronchoalveolar lavage (BAL) compared with saline treated animals; albumin concentrations in BAL are increased >1.5-fold compared to treated wild-type mice at 2, 5, and 7 days after bleomycin treatment

• IgM concentrations also increase in the week following bleomycin, but it does not reach significance compared to wild-type

Allelic Composition	Timp1^tm1Pds/Timp1^tm1Pds
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Timp1^tm1Pds mutation (1 available); any Timp1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to bacterial infection ( J:94836 )

• 16 days after infection, inflammation is resolved and corneal integrity restored unlike in C57BL/6 wild-type mice

Allelic Composition	Mmp2^tm1Ito/Mmp2^tm1Ito Timp1^tm1Pds/Timp1^tm1Pds
Genetic Background	either: (involves: 129S4/SvJae) or (involves: C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp2^tm1Ito mutation (1 available); any Mmp2 mutation (25 available)
Timp1^tm1Pds mutation (1 available); any Timp1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to bacterial infection ( J:94836 )

• resistance to corneal infection is similar to Timp1 single homozygotes

Allelic Composition	Mmp12^tm1Sds/Mmp12^tm1Sds Timp1^tm1Pds/Timp1^tm1Pds
Genetic Background	either: (involves: 129S4/SvJae) or (involves: C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp12^tm1Sds mutation (1 available); any Mmp12 mutation (36 available)
Timp1^tm1Pds mutation (1 available); any Timp1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to bacterial infection ( J:94836 )

• resistance to corneal infection is similar to Timp1 single homozygotes

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Timp1^tm1Pds/Y
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (33 available); any Apoe mutation (156 available)
Timp1^tm1Pds mutation (1 available); any Timp1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal blood vessel physiology ( J:103082 )

• males fed an atherogenic, high-fat diet for 10 or 22 weeks develop a higher number of ruptures in the aortic media, in which all elastic laminae are digested and infiltrated with macrophages and form pseudo-microaneurysms, than single homozygous Apoe^tm1Unc mutant males

Allelic Composition	Mmp7^tm1Lmm/Mmp7^tm1Lmm Timp1^tm1Pds/Timp1^tm1Pds
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp7^tm1Lmm mutation (1 available); any Mmp7 mutation (21 available)
Timp1^tm1Pds mutation (1 available); any Timp1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to bacterial infection ( J:94836 )

• bacterial clearance following corneal infection is increased compared to wild-type mice, however clearance is decreased compared to Timp1 single homozygotes

Allelic Composition	Mmp9^tm1Tvu/Mmp9^tm1Tvu Timp1^tm1Pds/Timp1^tm1Pds
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp9^tm1Tvu mutation (2 available); any Mmp9 mutation (50 available)
Timp1^tm1Pds mutation (1 available); any Timp1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:94836 )

N	• double mutants are as susceptible to corneal bacterial infection as wild-type mice unlike Timp1 single homozygotes which show decreased susceptibility

Allelic Composition	Mmp3^tm1Mrl/Mmp3^tm1Mrl Timp1^tm1Pds/Timp1^tm1Pds
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp3^tm1Mrl mutation (0 available); any Mmp3 mutation (33 available)
Timp1^tm1Pds mutation (1 available); any Timp1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to bacterial infection ( J:94836 )

• after infection, inflammation is resolved and corneal integrity restored unlike in C57BL/6 wild-type mice, however resistance is decreased compared to Timp1 single homozygotes

Allelic Composition	Timp1^tm1Pds/Y
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Timp1^tm1Pds mutation (1 available); any Timp1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

aortic aneurysm ( J:101938 , J:102182 )

• mutants form significantly larger aneurysms than wild-type after elastase infusion to induce aneurysm formation (to model abdominal aortic aneurysm) (J:101938)

• mutants, unlike wild-type, also develop aneurysms following saline injection (J:101938)

• hemizygotes show increased and continued progression of aneurysm formation compared with wild-type in a thoracic aortic aneurysm model (induced by calcium chloride treatment) (J:102182)

increased left ventricle diastolic pressure ( J:60524 )

• increased left ventricle end-diastolic pressure and volume vs. wild-type controls

abnormal response to cardiac infarction ( J:95572 )

endocrine/exocrine glands

increased testis weight ( J:49303 )

• increased testicular weight at day 21 after birth

growth/size/body

growth/size/body region phenotype ( J:49303 )

N	• body weight equivalent to controls at same age

homeostasis/metabolism

abnormal response to cardiac infarction ( J:95572 )

increased circulating testosterone level ( J:49303 )

• only at day 21 after birth

reproductive system

increased testis weight ( J:49303 )

• increased testicular weight at day 21 after birth

Allelic Composition	Timp1^tm1Pds/Y
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Timp1^tm1Pds mutation (1 available); any Timp1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:211441 )

N	• whether or not infused with angiotensin II, mice exhibit normal heart rate

abnormal systemic arterial blood pressure ( J:211441 )

• following angiotensin II infusion, mice less of an increase in blood pressure compared with wild-type mice

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