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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Bin3tm1Gcp
targeted mutation 1, George C Prendergast
MGI:3512131
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Bin3tm1Gcp/Bin3tm1Gcp involves: 129 * C57BL/6 MGI:3810484


Genotype
MGI:3810484
hm1
Allelic
Composition
Bin3tm1Gcp/Bin3tm1Gcp
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bin3tm1Gcp mutation (0 available); any Bin3 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• numerous large vacuoles in the lens cortex by 8 months of age
• loss of F-actin in lens fiber cells
• develop in the lenses of one or both eyes within a few weeks or months of birth
• in all homozygotes by 6 months

neoplasm
• increased incidence of lymphoma after 1 year of age
• found in 36% of homozygotes by 18 months
• in lung, liver, intestine, spleen, lymph nodes
• mucosa-associated and follicular lymphomas
• greater sensitivity to radiation induced lung adenocarcinoma
• greater sensitivity to radiation induced lung adenocarcinoma

respiratory system
• increased incidence of congestion and inflammation
• greater sensitivity to radiation induced lung adenocarcinoma

liver/biliary system
• increased incidence of congestion and inflammation
• in mice treated with diethylnitrosamine

hematopoietic system
• splenomegaly develops in response to radiation treatment or treatment with diethylnitrosamine
• myelodysplasic syndrome

immune system
• splenomegaly develops in response to radiation treatment or treatment with diethylnitrosamine
• increased incidence of congestion and inflammation
• increased incidence of congestion and inflammation

growth/size/body
• splenomegaly develops in response to radiation treatment or treatment with diethylnitrosamine





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory