vision/eye
• numerous large vacuoles in the lens cortex by 8 months of age
• loss of F-actin in lens fiber cells
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• develop in the lenses of one or both eyes within a few weeks or months of birth
• in all homozygotes by 6 months
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neoplasm
• increased incidence of lymphoma after 1 year of age
• found in 36% of homozygotes by 18 months
• in lung, liver, intestine, spleen, lymph nodes
• mucosa-associated and follicular lymphomas
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• greater sensitivity to radiation induced lung adenocarcinoma
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• greater sensitivity to radiation induced lung adenocarcinoma
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respiratory system
• increased incidence of congestion and inflammation
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• greater sensitivity to radiation induced lung adenocarcinoma
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liver/biliary system
• increased incidence of congestion and inflammation
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• in mice treated with diethylnitrosamine
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hematopoietic system
• splenomegaly develops in response to radiation treatment or treatment with diethylnitrosamine
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• in spleen
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immune system
• splenomegaly develops in response to radiation treatment or treatment with diethylnitrosamine
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• increased incidence of congestion and inflammation
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• increased incidence of congestion and inflammation
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growth/size/body
• splenomegaly develops in response to radiation treatment or treatment with diethylnitrosamine
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