Phenotypes associated with this allele

• Allele Symbol: Grin3b^tm1Yaha
• Allele Name: targeted mutation 1, Yasunori Hayashi
• Allele ID: MGI:3512173
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grin3b^tm1Yaha/Grin3b^tm1Yaha	B6.129-Grin3b^tm1Yaha	MGI:3762969

Genotype
MGI:3762969

hm1

• Allelic Composition: Grin3b^tm1Yaha/Grin3b^tm1Yaha
• Genetic Background: B6.129-Grin3b^tm1Yaha

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

slow postnatal weight gain ( J:126239 )

• decreased body weight becomes apparent at around 16-18 weeks of age and persists through 13 weeks

• food and water intake are normal

behavior/neurological

increased anxiety-related response ( J:126239 )

• reduced interactions with unknown animals when in a novel environment

• reduced stereotypic activity in a novel environment

• less frequent entry into the arms of an elevated plus maze, particularly the open arms

• less time spent in the arms of an elevated plus maze

abnormal motor capabilities/coordination/movement ( J:126239 )

impaired coordination ( J:126239 )

• mild impairment as indicated by an accelerating rotarod test

• no improvement with practice

• shorter distances walked in "beam" tests

decreased locomotor activity ( J:126239 )

• reduced home cage activity

• generally hypoactive

abnormal social/conspecific interaction behavior ( J:126239 )

• increased social activity with familiar cagemates

abnormal social investigation ( J:126239 )

• reduced interactions with unknown animals when in a novel environment