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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sh2d1atm1Vei
targeted mutation 1, Andre Veillette
MGI:3512182
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sh2d1atm1Vei/Sh2d1atm1Vei B6.129-Sh2d1atm1Vei MGI:5438037
hm2
 		Sh2d1atm1Vei/Sh2d1atm1Vei involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3809400
cx3
 		Sh2d1atm1Vei/Sh2d1atm1Vei
Sh2d1b1tm3Vei/Sh2d1b1tm3Vei 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5438038


Genotype
MGI:5438037
hm1
Allelic
Composition		 Sh2d1atm1Vei/Sh2d1atm1Vei
Genetic
Background		 B6.129-Sh2d1atm1Vei
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm1Vei mutation (0 available); any Sh2d1a mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal NK cell physiology ( J:187430 )
• NK cells exhibit severely decreased killing of hematopoietic cells RMA-S, YAC-1 and MHC class I-deficient splenocytes in vitro compared with wild-type cells
• mice exhibit a 5-fold increase in residual RMA-S cells in the peritoneal cavity compared with wild-type mice
• when 2B4 is engaged, the activating effect is inhibited compared to on wild-type cells
• NK cells exhibit reduced conjugation with RMA-S cells compared with wild-type cells
• defects are not as severe as in Sh2d1atm1Pls homozygotes
• however, response to hamster CHO cells is normal

hematopoietic system
abnormal NK cell physiology ( J:187430 )
• NK cells exhibit severely decreased killing of hematopoietic cells RMA-S, YAC-1 and MHC class I-deficient splenocytes in vitro compared with wild-type cells
• mice exhibit a 5-fold increase in residual RMA-S cells in the peritoneal cavity compared with wild-type mice
• when 2B4 is engaged, the activating effect is inhibited compared to on wild-type cells
• NK cells exhibit reduced conjugation with RMA-S cells compared with wild-type cells
• defects are not as severe as in Sh2d1atm1Pls homozygotes
• however, response to hamster CHO cells is normal




Genotype
MGI:3809400
hm2
Allelic
Composition		 Sh2d1atm1Vei/Sh2d1atm1Vei
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm1Vei mutation (0 available); any Sh2d1a mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgE level ( J:93886 )
• after immunization with ovalbumin, severe deficit in IgE is observed with little or no Ig E detected; levels are slightly higher than in Sh2d1atm1Pls mice
abnormal CD4-positive, alpha-beta T cell physiology ( J:93886 )
• cells exhibit impaired IL-4 and IL-13 production upon stimulation with anti-CD3, anti-CD3 and anti-CD28 or PMA plus ionomycin
• naive CD4+ T cells have deficit in IL-4 production
abnormal memory T cell physiology ( J:93886 )
• function deficit of memory-type CD4+ T cells results in Th2 dysfunction (IL-4 production)

hematopoietic system
decreased IgE level ( J:93886 )
• after immunization with ovalbumin, severe deficit in IgE is observed with little or no Ig E detected; levels are slightly higher than in Sh2d1atm1Pls mice
abnormal CD4-positive, alpha-beta T cell physiology ( J:93886 )
• cells exhibit impaired IL-4 and IL-13 production upon stimulation with anti-CD3, anti-CD3 and anti-CD28 or PMA plus ionomycin
• naive CD4+ T cells have deficit in IL-4 production
abnormal memory T cell physiology ( J:93886 )
• function deficit of memory-type CD4+ T cells results in Th2 dysfunction (IL-4 production)




Genotype
MGI:5438038
cx3
Allelic
Composition		 Sh2d1atm1Vei/Sh2d1atm1Vei
Sh2d1b1tm3Vei/Sh2d1b1tm3Vei
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm1Vei mutation (0 available); any Sh2d1a mutation (11 available)
Sh2d1b1tm3Vei mutation (0 available); any Sh2d1b1 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal NK cell physiology ( J:187430 )
• decreased killing of RMA-S

hematopoietic system
abnormal NK cell physiology ( J:187430 )
• decreased killing of RMA-S




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory