Phenotypes associated with this allele

• Allele Symbol: Txnrd2^tm1Marc
• Allele Name: targeted mutation 1, Marcus Conrad
• Allele ID: MGI:3512408
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Myl2^tm1(cre)Krc/Myl2^+ Txnrd2^tm1Marc/Txnrd2^tm1.1Marc	involves: 129P2/OlaHsd * C57BL/6	MGI:3512422
cn2	Txnrd2^tm1Marc/Txnrd2^tm1Marc Tg(Nes-cre)1Kln/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:3778635

Genotype
MGI:3512422

cn1

• Allelic Composition: Myl2^tm1(cre)Krc/Myl2⁺; Txnrd2^tm1Marc/Txnrd2^tm1.1Marc
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:94136 )

• mutants die within several hours after birth

cardiovascular system

liver vascular congestion ( J:94136 )

• liver congestion

abnormal myocardial fiber morphology ( J:94136 )

• myocardial cells are severely distorted with pycnotic nuclei, cytoplasmic vacuolization, reduced cross-striation, and swollen or destroyed mitochondrial cristae

dilated heart atrium ( J:94136 )

globular heart ( J:94136 )

• globular heart shape

thin ventricular wall ( J:94136 )

congestive heart failure ( J:94136 )

• mutants show clinical features of congestive heart failure

homeostasis/metabolism

edema ( J:94136 )

liver/biliary system

liver vascular congestion ( J:94136 )

• liver congestion

muscle

abnormal myocardial fiber morphology ( J:94136 )

• myocardial cells are severely distorted with pycnotic nuclei, cytoplasmic vacuolization, reduced cross-striation, and swollen or destroyed mitochondrial cristae

Genotype
MGI:3778635

cn2

• Allelic Composition: Txnrd2^tm1Marc/Txnrd2^tm1Marc; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

nervous system

nervous system phenotype ( J:133173 )

N • mice exhibit normal brain morphology

normal phenotype

no abnormal phenotype detected ( J:133173 )

• mice do not display any overt phenotype