All Phenotypes Txnrd2<tm1.1Marc> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Txnrd2^tm1.1Marc/Txnrd2^tm1.1Marc	involves: 129P2/OlaHsd * C57BL/6	MGI:3512435
cn2	Myl2^tm1(cre)Krc/Myl2⁺ Txnrd2^tm1Marc/Txnrd2^tm1.1Marc	involves: 129P2/OlaHsd * C57BL/6	MGI:3512422

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:94136 )

• homozygotes die between E12.5 and E13.5

cardiovascular system

abnormal heart morphology ( J:94136 )

• at E13.0 dysplasia of the cardiac tissues is seen

trabecula carnea hypoplasia ( J:94136 )

• the trabeculae are thinner than normal at E13.0

thin interventricular septum ( J:94136 )

• the ventricular septum is thinner than normal at E13.0

thin ventricular wall ( J:94136 )

abnormal blood flow velocity ( J:94136 )

• bloodstream velocity is decreased at E13.0 in living homozygotes

decreased fetal cardiomyocyte proliferation ( J:94136 )

• cardiomyocyte proliferation is reduced, but no increase in apoptosis is detected

cellular

decreased fetal cardiomyocyte proliferation ( J:94136 )

• cardiomyocyte proliferation is reduced, but no increase in apoptosis is detected

decreased fibroblast proliferation ( J:94136 )

• proliferation of mutant MEFs is significantly slower

hematopoietic system

abnormal definitive hematopoiesis ( J:94136 )

• at E11 and E12.5 increased apoptosis of embryonic blood cells in the liver and reduced size of blood cell colonies formed in a CFU assay are seen

anemia ( J:94136 )

• blood vessels in the yolk sac and embryo contain less blood at E13.5; however, vessel morphology is normal

liver/biliary system

abnormal liver morphology ( J:94136 )

• the liver appears pleiomorphic and spongiform at E11

muscle

trabecula carnea hypoplasia ( J:94136 )

• the trabeculae are thinner than normal at E13.0

decreased fetal cardiomyocyte proliferation ( J:94136 )

• cardiomyocyte proliferation is reduced, but no increase in apoptosis is detected

Allelic Composition	Myl2^tm1(cre)Krc/Myl2⁺ Txnrd2^tm1Marc/Txnrd2^tm1.1Marc
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myl2^tm1(cre)Krc mutation (2 available); any Myl2 mutation (22 available)
Txnrd2^tm1.1Marc mutation (0 available); any Txnrd2 mutation (18 available)
Txnrd2^tm1Marc mutation (0 available); any Txnrd2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:94136 )

• mutants die within several hours after birth

cardiovascular system

liver vascular congestion ( J:94136 )

• liver congestion

abnormal myocardial fiber morphology ( J:94136 )

• myocardial cells are severely distorted with pycnotic nuclei, cytoplasmic vacuolization, reduced cross-striation, and swollen or destroyed mitochondrial cristae

dilated heart atrium ( J:94136 )

globular heart ( J:94136 )

• globular heart shape

thin ventricular wall ( J:94136 )

congestive heart failure ( J:94136 )

• mutants show clinical features of congestive heart failure

homeostasis/metabolism

edema ( J:94136 )

liver/biliary system

liver vascular congestion ( J:94136 )

• liver congestion

muscle

abnormal myocardial fiber morphology ( J:94136 )

• myocardial cells are severely distorted with pycnotic nuclei, cytoplasmic vacuolization, reduced cross-striation, and swollen or destroyed mitochondrial cristae

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