Phenotypes associated with this allele

• Allele Symbol: Smad2^tm1Mwst
• Allele Name: targeted mutation 1, Michael Weinstein
• Allele ID: MGI:3512447
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smad2^tm1Mwst/Smad2^tm1Mwst	involves: 129S6/SvEvTac * Black Swiss	MGI:3513601
ht2	Smad2^tm1Mwst/Smad2^tm1.2Mwst	involves: 129S6/SvEvTac * Black Swiss	MGI:3513602
ht3	Smad2^tm1Cxd/Smad2^tm1Mwst	involves: 129S6/SvEvTac * Black Swiss	MGI:3513603

Genotype
MGI:3513601

hm1

• Allelic Composition: Smad2^tm1Mwst/Smad2^tm1Mwst
• Genetic Background: involves: 129S6/SvEvTac * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:94232 )

• homozygotes are viable with no obvious abnormalities

Genotype
MGI:3513602

ht2

• Allelic Composition: Smad2^tm1Mwst/Smad2^tm1.2Mwst
• Genetic Background: involves: 129S6/SvEvTac * Black Swiss

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:94232 )

• homozygous embryos die before E11.5

embryo

abnormal developmental patterning ( J:94232 )

• three classes of mutant embryos are seen, those consisting of an empty yolk sac, those that have a mass of tissue attached to the distal tip of the yolk sac, and those that have severe midline defects

Genotype
MGI:3513603

ht3

• Allelic Composition: Smad2^tm1Cxd/Smad2^tm1Mwst
• Genetic Background: involves: 129S6/SvEvTac * Black Swiss

mortality/aging

embryonic lethality, complete penetrance ( J:94232 )

• homozygous embryos die before E11.5