All Phenotypes Smad2<tm1.1Mwst> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smad2^tm1.1Mwst/Smad2^tm1.1Mwst	involves: 129S6/SvEvTac * Black Swiss	MGI:3513604
ht2	Smad2^tm1.1Mwst/Smad2^tm1.2Mwst	involves: 129S6/SvEvTac * Black Swiss	MGI:3513605
cn3	Amhr2^tm3(cre)Bhr/Amhr2⁺ Smad2^tm1Cxd/Smad2^tm1.1Mwst Smad3^tm1Par/Smad3^tm1Zuk	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3822485
cn4	Amhr2^tm3(cre)Bhr/Amhr2⁺ Smad2^tm1Cxd/Smad2^tm1.1Mwst	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6	MGI:3822483

Allelic Composition	Smad2^tm1.1Mwst/Smad2^tm1.1Mwst
Genetic Background	involves: 129S6/SvEvTac * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad2^tm1.1Mwst mutation (0 available); any Smad2 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:94232 )

• homozygotes are viable with no obvious abnormalities

Allelic Composition	Smad2^tm1.1Mwst/Smad2^tm1.2Mwst
Genetic Background	involves: 129S6/SvEvTac * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad2^tm1.1Mwst mutation (0 available); any Smad2 mutation (52 available)
Smad2^tm1.2Mwst mutation (0 available); any Smad2 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:94232 )

• mutants are viable with no obvious abnormalities

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased oocyte number ( J:142827 )

• in superovulation experiments, mice ovulate half as many oocytes as wild-type mice

reproductive system

decreased oocyte number ( J:142827 )

• in superovulation experiments, mice ovulate half as many oocytes as wild-type mice

abnormal ovarian follicle morphology ( J:142827 )

• at 3 months, mice contain luteinizing follicles that encompass trapped oocytes unlike in wild-type mice

• at 8 months, mice exhibit more severe follicular abnormalities than at 3 moths with aberrant cumulus cell-oocytes unlike in wild-type mice

decreased tertiary ovarian follicle number ( J:142827 )

• at 3 months, fewer antral follicles are present compared to in wild-type ovaries

increased atretic ovarian follicle number ( J:142827 )

• at 3 months, a marker of follicular atresia accumulates unlike in wild-type ovaries

abnormal cumulus expansion ( J:142827 )

• treatment with pregnant mare serum gonadotropin (PMSG) induces only minimal cumulus expansion unlike in similarly treated wild-type mice and few cumulus cells attach to oocytes

• in culture, cumulus cells undergo disorganized and limited expansion in response to EGF compared to similarly treated wild-type cells

• in culture, cumulus cells stimulated by EGF detach from the cumulus oocyte complexes and attach to the culture plate leaving 18% of oocytes denuded unlike wild-type cells

premature ovarian failure ( J:142827 )

• females exhibit reduced fertility and premature ovarian failure becoming infertile after 4 months of breeding unlike in wild-type mice

reduced female fertility ( J:142827 )

decreased litter size ( J:142827 )

homeostasis/metabolism

increased circulating follicle stimulating hormone level ( J:142827 )

• at 8 months

increased circulating luteinizing hormone level ( J:142827 )

• at 8 months

mortality/aging

premature ovarian failure ( J:142827 )

• females exhibit reduced fertility and premature ovarian failure becoming infertile after 4 months of breeding unlike in wild-type mice

endocrine/exocrine glands

abnormal ovarian follicle morphology ( J:142827 )

• at 3 months, mice contain luteinizing follicles that encompass trapped oocytes unlike in wild-type mice

• at 8 months, mice exhibit more severe follicular abnormalities than at 3 moths with aberrant cumulus cell-oocytes unlike in wild-type mice

decreased tertiary ovarian follicle number ( J:142827 )

• at 3 months, fewer antral follicles are present compared to in wild-type ovaries

increased atretic ovarian follicle number ( J:142827 )

• at 3 months, a marker of follicular atresia accumulates unlike in wild-type ovaries

abnormal cumulus expansion ( J:142827 )

• treatment with pregnant mare serum gonadotropin (PMSG) induces only minimal cumulus expansion unlike in similarly treated wild-type mice and few cumulus cells attach to oocytes

• in culture, cumulus cells undergo disorganized and limited expansion in response to EGF compared to similarly treated wild-type cells

• in culture, cumulus cells stimulated by EGF detach from the cumulus oocyte complexes and attach to the culture plate leaving 18% of oocytes denuded unlike wild-type cells

premature ovarian failure ( J:142827 )

• females exhibit reduced fertility and premature ovarian failure becoming infertile after 4 months of breeding unlike in wild-type mice

Allelic Composition	Amhr2^tm3(cre)Bhr/Amhr2⁺ Smad2^tm1Cxd/Smad2^tm1.1Mwst
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2^tm3(cre)Bhr mutation (1 available); any Amhr2 mutation (29 available)
Smad2^tm1.1Mwst mutation (0 available); any Smad2 mutation (52 available)
Smad2^tm1Cxd mutation (0 available); any Smad2 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:142827 )

N	• mice exhibit normal reproductive morphology and physiology

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