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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Smad2tm1.1Mwst
targeted mutation 1.1, Michael Weinstein
MGI:3512448
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Smad2tm1.1Mwst/Smad2tm1.1Mwst involves: 129S6/SvEvTac * Black Swiss MGI:3513604
ht2
Smad2tm1.1Mwst/Smad2tm1.2Mwst involves: 129S6/SvEvTac * Black Swiss MGI:3513605
cn3
Amhr2tm3(cre)Bhr/Amhr2+
Smad2tm1Cxd/Smad2tm1.1Mwst
Smad3tm1Par/Smad3tm1Zuk
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3822485
cn4
Amhr2tm3(cre)Bhr/Amhr2+
Smad2tm1Cxd/Smad2tm1.1Mwst
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 MGI:3822483


Genotype
MGI:3513604
hm1
Allelic
Composition
Smad2tm1.1Mwst/Smad2tm1.1Mwst
Genetic
Background
involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad2tm1.1Mwst mutation (0 available); any Smad2 mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• homozygotes are viable with no obvious abnormalities




Genotype
MGI:3513605
ht2
Allelic
Composition
Smad2tm1.1Mwst/Smad2tm1.2Mwst
Genetic
Background
involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad2tm1.1Mwst mutation (0 available); any Smad2 mutation (52 available)
Smad2tm1.2Mwst mutation (0 available); any Smad2 mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mutants are viable with no obvious abnormalities




Genotype
MGI:3822485
cn3
Allelic
Composition
Amhr2tm3(cre)Bhr/Amhr2+
Smad2tm1Cxd/Smad2tm1.1Mwst
Smad3tm1Par/Smad3tm1Zuk
Genetic
Background
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2tm3(cre)Bhr mutation (1 available); any Amhr2 mutation (29 available)
Smad2tm1.1Mwst mutation (0 available); any Smad2 mutation (52 available)
Smad2tm1Cxd mutation (0 available); any Smad2 mutation (52 available)
Smad3tm1Par mutation (2 available); any Smad3 mutation (22 available)
Smad3tm1Zuk mutation (0 available); any Smad3 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• in superovulation experiments, mice ovulate half as many oocytes as wild-type mice

reproductive system
• in superovulation experiments, mice ovulate half as many oocytes as wild-type mice
• at 3 months, mice contain luteinizing follicles that encompass trapped oocytes unlike in wild-type mice
• at 8 months, mice exhibit more severe follicular abnormalities than at 3 moths with aberrant cumulus cell-oocytes unlike in wild-type mice
• at 3 months, fewer antral follicles are present compared to in wild-type ovaries
• at 3 months, a marker of follicular atresia accumulates unlike in wild-type ovaries
• treatment with pregnant mare serum gonadotropin (PMSG) induces only minimal cumulus expansion unlike in similarly treated wild-type mice and few cumulus cells attach to oocytes
• in culture, cumulus cells undergo disorganized and limited expansion in response to EGF compared to similarly treated wild-type cells
• in culture, cumulus cells stimulated by EGF detach from the cumulus oocyte complexes and attach to the culture plate leaving 18% of oocytes denuded unlike wild-type cells
• females exhibit reduced fertility and premature ovarian failure becoming infertile after 4 months of breeding unlike in wild-type mice

homeostasis/metabolism

mortality/aging
• females exhibit reduced fertility and premature ovarian failure becoming infertile after 4 months of breeding unlike in wild-type mice

endocrine/exocrine glands
• at 3 months, mice contain luteinizing follicles that encompass trapped oocytes unlike in wild-type mice
• at 8 months, mice exhibit more severe follicular abnormalities than at 3 moths with aberrant cumulus cell-oocytes unlike in wild-type mice
• at 3 months, fewer antral follicles are present compared to in wild-type ovaries
• at 3 months, a marker of follicular atresia accumulates unlike in wild-type ovaries
• treatment with pregnant mare serum gonadotropin (PMSG) induces only minimal cumulus expansion unlike in similarly treated wild-type mice and few cumulus cells attach to oocytes
• in culture, cumulus cells undergo disorganized and limited expansion in response to EGF compared to similarly treated wild-type cells
• in culture, cumulus cells stimulated by EGF detach from the cumulus oocyte complexes and attach to the culture plate leaving 18% of oocytes denuded unlike wild-type cells
• females exhibit reduced fertility and premature ovarian failure becoming infertile after 4 months of breeding unlike in wild-type mice




Genotype
MGI:3822483
cn4
Allelic
Composition
Amhr2tm3(cre)Bhr/Amhr2+
Smad2tm1Cxd/Smad2tm1.1Mwst
Genetic
Background
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2tm3(cre)Bhr mutation (1 available); any Amhr2 mutation (29 available)
Smad2tm1.1Mwst mutation (0 available); any Smad2 mutation (52 available)
Smad2tm1Cxd mutation (0 available); any Smad2 mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• mice exhibit normal reproductive morphology and physiology





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory