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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Smad2tm1.2Mwst
targeted mutation 1.2, Michael Weinstein
MGI:3512449
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Smad2tm1.2Mwst/Smad2tm1.2Mwst involves: 129S6/SvEvTac * Black Swiss MGI:3513606
ht2
 		Smad2tm1.2Mwst/Smad2+ involves: 129S6/SvEvTac * Black Swiss MGI:3513666
ht3
 		Smad2tm1Mwst/Smad2tm1.2Mwst involves: 129S6/SvEvTac * Black Swiss MGI:3513602
ht4
 		Smad2tm1.1Mwst/Smad2tm1.2Mwst involves: 129S6/SvEvTac * Black Swiss MGI:3513605


Genotype
MGI:3513606
hm1
Allelic
Composition		 Smad2tm1.2Mwst/Smad2tm1.2Mwst
Genetic
Background		 involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad2tm1.2Mwst mutation (0 available); any Smad2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
decreased embryo size ( J:94232 )
• at E7.5 homozygous embryos are much smaller compared to wildtype and have the same phenotype as Smad2tm1Cxd homozygotes

growth/size/body
decreased embryo size ( J:94232 )
• at E7.5 homozygous embryos are much smaller compared to wildtype and have the same phenotype as Smad2tm1Cxd homozygotes




Genotype
MGI:3513666
ht2
Allelic
Composition		 Smad2tm1.2Mwst/Smad2+
Genetic
Background		 involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad2tm1.2Mwst mutation (0 available); any Smad2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal developmental patterning ( J:94232 )
• about 10% of heterozygotes are external to the yolk sac




Genotype
MGI:3513602
ht3
Allelic
Composition		 Smad2tm1Mwst/Smad2tm1.2Mwst
Genetic
Background		 involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad2tm1.2Mwst mutation (0 available); any Smad2 mutation (50 available)
Smad2tm1Mwst mutation (0 available); any Smad2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:94232 )
• homozygous embryos die before E11.5

embryo
abnormal developmental patterning ( J:94232 )
• three classes of mutant embryos are seen, those consisting of an empty yolk sac, those that have a mass of tissue attached to the distal tip of the yolk sac, and those that have severe midline defects




Genotype
MGI:3513605
ht4
Allelic
Composition		 Smad2tm1.1Mwst/Smad2tm1.2Mwst
Genetic
Background		 involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad2tm1.1Mwst mutation (0 available); any Smad2 mutation (50 available)
Smad2tm1.2Mwst mutation (0 available); any Smad2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:94232 )
• mutants are viable with no obvious abnormalities




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/24/2024
MGI 6.24 		The Jackson Laboratory