Phenotypes associated with this allele

• Allele Symbol: Mhstq2^{M. macedonius}
• Allele Name: M. macedonius
• Allele ID: MGI:3512501
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mhstq2^M. macedonius/Mhstq2^M. macedonius	involves: C57BL/6J * M. macedonius	MGI:3512502

Genotype
MGI:3512502

hm1

• Allelic Composition: Mhstq2^{M. macedonius}/Mhstq2^{M. macedonius}
• Genetic Background: involves: C57BL/6J * M. macedonius

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

azoospermia ( J:94029 )

♂ • no sperm are produced

abnormal sperm head morphology ( J:94029 )

♂ • in rare cases, abnormal sperm heads are observed

absent sperm head ( J:94029 )

♂ • most males do not produce sperm heads

abnormal male meiosis ( J:94029 )

♂ • either no meiotic metaphase I or only one metaphase are observed

♂ • rare entry into meiosis appears to lead to death of male germ cells

abnormal seminiferous tubule morphology ( J:94029 )

♂ • all seminiferous tubules contain vacuoles

♂ • only Sertoli cells and spermatogonia are observed

♂ • general disorganization of tubule contents and large intertubular area are observed

small seminiferous tubules ( J:94029 )

♂ • all seminiferous tubules are narrow

decreased testis weight ( J:94029 )

♂ • testis weight is 25% of normal adult testis weight and does not exceed that for 3-wk-old males

male infertility ( J:94029 )

♂

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:94029 )

♂ • all seminiferous tubules contain vacuoles

♂ • only Sertoli cells and spermatogonia are observed

♂ • general disorganization of tubule contents and large intertubular area are observed

small seminiferous tubules ( J:94029 )

♂ • all seminiferous tubules are narrow

decreased testis weight ( J:94029 )

♂ • testis weight is 25% of normal adult testis weight and does not exceed that for 3-wk-old males

hematopoietic system

thrombocytopenia ( J:94029 )

♀ • platelet numbers are below normal

cellular

azoospermia ( J:94029 )

♂ • no sperm are produced

abnormal sperm head morphology ( J:94029 )

♂ • in rare cases, abnormal sperm heads are observed

absent sperm head ( J:94029 )

♂ • most males do not produce sperm heads

abnormal male meiosis ( J:94029 )

♂ • either no meiotic metaphase I or only one metaphase are observed

♂ • rare entry into meiosis appears to lead to death of male germ cells