All Phenotypes Disp1<tm2Amc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Disp1^tm2Amc
targeted mutation 2, Andrew P McMahon
MGI:3512541

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Disp1^tm2Amc/Disp1^tm2Amc	involves: 129/Sv * C57BL/6J * SWR	MGI:3513043
cn2	Disp1^tm2.1Amc/Disp1^tm2Amc Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129/Sv * C57BL/6J * SWR	MGI:3513044
cn3	Disp1^icb/Disp1^tm2Amc Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129/Sv * C57BL/6J * SWR	MGI:3513048

Allelic Composition	Disp1^tm2Amc/Disp1^tm2Amc
Genetic Background	involves: 129/Sv * C57BL/6J * SWR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1^tm2Amc mutation (1 available); any Disp1 mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:94270 )

• homozygotes are viable with no gross abnormalities

Allelic Composition	Disp1^tm2.1Amc/Disp1^tm2Amc Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129/Sv * C57BL/6J * SWR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1^tm2.1Amc mutation (0 available); any Disp1 mutation (61 available)
Disp1^tm2Amc mutation (1 available); any Disp1 mutation (61 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality ( J:94270 )

craniofacial

abnormal parietal bone morphology ( J:94270 )

• ossification of the parietal bone is delayed

absent premaxilla ( J:94270 )

abnormal nasal pit morphology ( J:94270 )

• abnormally close association of the nasal pits

abnormal facial morphology ( J:94270 )

• facial midline defects are seen

skeleton

abnormal parietal bone morphology ( J:94270 )

• ossification of the parietal bone is delayed

absent premaxilla ( J:94270 )

nervous system

abnormal neuron differentiation ( J:94270 )

• the ventral midline cells are an intermediate state between pV3 and floor plate and fewer ventral progenitor cells are seen

respiratory system

abnormal nasal pit morphology ( J:94270 )

• abnormally close association of the nasal pits

cellular

abnormal neuron differentiation ( J:94270 )

• the ventral midline cells are an intermediate state between pV3 and floor plate and fewer ventral progenitor cells are seen

growth/size/body

abnormal facial morphology ( J:94270 )

• facial midline defects are seen

Allelic Composition	Disp1^icb/Disp1^tm2Amc Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129/Sv * C57BL/6J * SWR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1^icb mutation (0 available); any Disp1 mutation (61 available)
Disp1^tm2Amc mutation (1 available); any Disp1 mutation (61 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality ( J:94270 )

craniofacial

absent parietal bone ( J:94270 )

absent premaxilla ( J:94270 )

abnormal nasal pit morphology ( J:94270 )

• fusion of the nasal pits

abnormal facial morphology ( J:94270 )

• facial midline defects are seen

skeleton

absent parietal bone ( J:94270 )

absent premaxilla ( J:94270 )

nervous system

abnormal neuron differentiation ( J:94270 )

• pMN and pV3 progenitor cells are found at the midline and are reduced in numbers to less than 10% wild-type

absent floor plate ( J:94270 )

embryo

absent floor plate ( J:94270 )

respiratory system

abnormal nasal pit morphology ( J:94270 )

• fusion of the nasal pits

cellular

abnormal neuron differentiation ( J:94270 )

• pMN and pV3 progenitor cells are found at the midline and are reduced in numbers to less than 10% wild-type

growth/size/body

abnormal facial morphology ( J:94270 )

• facial midline defects are seen

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