About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Disp1tm2.1Amc
targeted mutation 2.1, Andrew P McMahon
MGI:3512545
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Disp1tm2.1Amc/Disp1tm2Amc
Shhtm1(EGFP/cre)Cjt/Shh+ 		involves: 129/Sv * C57BL/6J * SWR MGI:3513044
cx2
 		Disp1tm2.1Amc/Disp1tm2.1Amc
Shhtm1Amc/Shh+ 		involves: 129/Sv * C57BL/6J * SWR MGI:3513050


Genotype
MGI:3513044
cn1
Allelic
Composition		 Disp1tm2.1Amc/Disp1tm2Amc
Shhtm1(EGFP/cre)Cjt/Shh+
Genetic
Background		 involves: 129/Sv * C57BL/6J * SWR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1tm2.1Amc mutation (0 available); any Disp1 mutation (61 available)
Disp1tm2Amc mutation (1 available); any Disp1 mutation (61 available)
Shhtm1(EGFP/cre)Cjt mutation (1 available); any Shh mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

craniofacial
abnormal parietal bone morphology ( J:94270 )
• ossification of the parietal bone is delayed
abnormal nasal pit morphology ( J:94270 )
• abnormally close association of the nasal pits
abnormal facial morphology ( J:94270 )
• facial midline defects are seen

skeleton
abnormal parietal bone morphology ( J:94270 )
• ossification of the parietal bone is delayed

nervous system
abnormal neuron differentiation ( J:94270 )
• the ventral midline cells are an intermediate state between pV3 and floor plate and fewer ventral progenitor cells are seen

respiratory system
abnormal nasal pit morphology ( J:94270 )
• abnormally close association of the nasal pits

cellular
abnormal neuron differentiation ( J:94270 )
• the ventral midline cells are an intermediate state between pV3 and floor plate and fewer ventral progenitor cells are seen

growth/size/body
abnormal facial morphology ( J:94270 )
• facial midline defects are seen




Genotype
MGI:3513050
cx2
Allelic
Composition		 Disp1tm2.1Amc/Disp1tm2.1Amc
Shhtm1Amc/Shh+
Genetic
Background		 involves: 129/Sv * C57BL/6J * SWR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1tm2.1Amc mutation (0 available); any Disp1 mutation (61 available)
Shhtm1Amc mutation (1 available); any Shh mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron differentiation ( J:94270 )
• the reduction of pMN and pV2 progenitors results in a decrease in motorneuron precursors that are also abnormally positioned at the ventral midline
absent floor plate ( J:94270 )
• the floor plate is absent and the ventral midline has reduced numbers of the ventral most neural progenitors

embryo
absent floor plate ( J:94270 )
• the floor plate is absent and the ventral midline has reduced numbers of the ventral most neural progenitors

cellular
abnormal neuron differentiation ( J:94270 )
• the reduction of pMN and pV2 progenitors results in a decrease in motorneuron precursors that are also abnormally positioned at the ventral midline




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory