Phenotypes associated with this allele

• Allele Symbol: Tgfbr2^tm1Sjkm
• Allele Name: targeted mutation 1, Seong-Jin Kim
• Allele ID: MGI:3512546
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tgfbr2^tm1Sjkm/Tgfbr2^+	Not Specified	MGI:3714274

Genotype
MGI:3714274

ht1

• Allelic Composition: Tgfbr2^tm1Sjkm/Tgfbr2⁺
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:71591 )

• treatment with diethylnitrosamine results in enhanced tumorigenesis (hepatic adenomas and carcinomas) in the liver compared to wild-type

• however, no increase in spontaneous liver tumor development is observed

liver/biliary system

increased hepatocyte proliferation ( J:71591 )

• proliferation index of hepatocytes is mildly increased compared to wild-type

• hepatocytes isolated from 15 day old, but not 9 month old, mutants are slightly less sensitive to the growth-inhibitory effect of Tgfb compared to wild-type

neoplasm

increased incidence of tumors by chemical induction ( J:71591 )

• treatment with diethylnitrosamine results in enhanced tumorigenesis (hepatic adenomas and carcinomas) in the liver compared to wild-type

• however, no increase in spontaneous liver tumor development is observed

cellular

increased hepatocyte proliferation ( J:71591 )

• proliferation index of hepatocytes is mildly increased compared to wild-type

• hepatocytes isolated from 15 day old, but not 9 month old, mutants are slightly less sensitive to the growth-inhibitory effect of Tgfb compared to wild-type