Analysis Tools
mortality/aging
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• died approximately 30 days after birth
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behavior/neurological
limb grasping
(
J:94227
)
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• retracted their hind feet and clenched their digits when suspended by tail
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• decreased performance in an inclined-platform test with fewer mice reaching the top and taking longer to climb to the top of the platform, however, 63% of mutants remained on the platform suggesting that muscle strength is not impaired
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• characterized by a progressive movement disorder beginning at P18
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• decreased mobility
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cardiovascular system
small heart
(
J:94227
)
cellular
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• only mutant MEFs contained abnormal mitochondria and the increase in the number of abnormal mitochondria following mitochondrial stress was greater in mutant MEFs, indicating increased sensitivity to stress
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• increased sensitivity to apoptosis induction by DNA-damaging agent etoposide
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• significant increase in the susceptibility of cultured primary cortical neurons to excitotoxic stimuli
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growth/size/body
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• runted mice showed a general decrease in organ size
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• failed to gain weight following weaning at P18
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hematopoietic system
small thymus
(
J:94227
)
small spleen
(
J:94227
)
immune system
small thymus
(
J:94227
)
small spleen
(
J:94227
)
nervous system
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• significant increase in the susceptibility of cultured primary cortical neurons to excitotoxic stimuli
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• at P30, brain was approximately 75% of the weight of wild-type
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• extracts from striata showed a significant decrease in the yield of mitochondrial citrate synthase suggesting decreased mitochondrial density
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• at P20 and P30, observed selective loss of a population of striatal neurons, just lateral of the thalamus in a posteriomedial portion of the basal ganglia, and loss of terminals of the nigrostriatal pathway
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homeostasis/metabolism
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• significant increase in the susceptibility of cultured primary cortical neurons to excitotoxic stimuli
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integument
sparse hair
(
J:94227
)
|
• hair loss was occasionally seen in mutants after P18
|
endocrine/exocrine glands
small thymus
(
J:94227
)
