behavior/neurological
N |
• behavior is similar to wild-type littermates
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Allele Symbol Allele Name Allele ID |
Gabbr1tm2Bet targeted mutation 2, Bernhard Bettler MGI:3512742 |
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Summary |
3 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• behavior is similar to wild-type littermates
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice appear indistinguishable from controls in health, behavior and appearance
• EEG or sleep-wake parameters during the 24 hour cycle do not differ from controls
• propofol-induced loss of righting reflex (LORR) is not different from controls
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• level of arousal (time spent in the wake phase) remains elevated for a longer period in mutants in response to a change of environment, compared to controls
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• tuberomammillary nucleus neurons in brain slices from mutant animals are not hyperpolarized by propofol treatment, as observed in control neurons
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• despite loss of Gabbr1 expression, no decrease in the number of orexin positive neurons is detected and spontaneous excitatory postsynaptic currents in orexin neurons are similar to controls
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• unlike in controls, treatment with bicuculline induces depolarization of orexin neurons
• membrane resistance of orexin neurons is significantly decreased
• glutamate and GABA-A agonists are less potent in inducing depolarizing currents in orexin neurons compared to controls
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• increase in the frequency of fast spontaneous inhibitory postsynaptic currents in orexin neurons compared to control littermates
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• severe fragmentation of the sleep wake cycle with decreased awake, non-REM, and REM sleep episode durations and reduced REM latency
• fragmentation occurs in both the light and dark phases
• the delta power is significantly increased in non-REM sleep and the theta power is decreased during REM sleep compared to controls
• however, the overall amounts of wakefulness, non-REM and REM sleep are similar to controls
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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