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Allele Symbol Allele Name Allele ID |
Rec8mei8 mei8, John Schimenti MGI:3512754 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• defect in telomere-nuclear envelope attachment
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• defect in telomere-nuclear envelope attachment
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• despite an absence of synapsis between homologs in spermatocytes, 28%-35% of spermatocytes exhibit homolog pairing in the chromosome mid- and subtelomeric regions
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• no spematocyte nuclei with 19 fully synapsed autosomes are detected
(J:94208)
• regional splitting of axial elements is seen at the early zygotene stage but is suppressed in later stages when double-strand break markers accumulate in spermatocytes
(J:209347)
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• spermatogenesis arrests at meiotic prophase I with no postmeiotic spermatids seen in the seminiferous tubules
(J:94208)
• spermatocytes form axial elements but they arrest at the leptotene/zygotene stage
(J:209347)
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• spermatocytes form axial elements but they arrest at the leptotene/zygotene stage with aberrant synaptonemal complex formation
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• only residual ovaries are seen in 6 week old females
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• at 5-6 weeks of age mutant testis are about 50% the size of wild-type
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• both males and females are infertile
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• only residual ovaries are seen in 6 week old females
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• at 5-6 weeks of age mutant testis are about 50% the size of wild-type
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• despite an absence of synapsis between homologs in spermatocytes, 28%-35% of spermatocytes exhibit homolog pairing in the chromosome mid- and subtelomeric regions
|
|
|
• no spematocyte nuclei with 19 fully synapsed autosomes are detected
(J:94208)
• regional splitting of axial elements is seen at the early zygotene stage but is suppressed in later stages when double-strand break markers accumulate in spermatocytes
(J:209347)
|
|
|
• spermatogenesis arrests at meiotic prophase I with no postmeiotic spermatids seen in the seminiferous tubules
(J:94208)
• spermatocytes form axial elements but they arrest at the leptotene/zygotene stage
(J:209347)
|
|
|
• spermatocytes form axial elements but they arrest at the leptotene/zygotene stage with aberrant synaptonemal complex formation
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
• spermatocytes exhibit axial element splitting in the zygotene-like stage
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• synaptonemal complex formation is largely abolished in spermatocytes
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• spermatocytes exhibit axial element splitting in the zygotene-like stage
|
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• synaptonemal complex formation is largely abolished in spermatocytes
|
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|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• males and females do not form either cohesion axes or chromosome axes
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• spermatocytes exhibit enhanced bouquet arrest
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• males and females do not form either cohesion axes or chromosome axes
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• spermatocytes exhibit enhanced bouquet arrest
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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