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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Shhtm5Amc
targeted mutation 5, Andrew P McMahon
MGI:3512786
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Disp1icb/Disp1icb
Shhtm1Amc/Shhtm5Amc
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: 129/Sv * C57BL/6J * SWR MGI:3513053


Genotype
MGI:3513053
cn1
Allelic
Composition		 Disp1icb/Disp1icb
Shhtm1Amc/Shhtm5Amc
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: 129/Sv * C57BL/6J * SWR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation (0 available); any Disp1 mutation (61 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (43 available)
Shhtm1Amc mutation (1 available); any Shh mutation (48 available)
Shhtm5Amc mutation (0 available); any Shh mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:94270 )
• compound mutants die around birth unlike Disp1 single homozygotes which die before E9.5

craniofacial
abnormal frontonasal prominence morphology ( J:94270 )
• midline defects in the frontal nasal process are seen, however many of the developmental defects seen in Disp1 single homozygotes are rescued in the compound mutants




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory