All Phenotypes repro2 MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

repro2
reproductive mutant 2, JAX Reproductive Mutagenesis Program
MGI:3512896

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	repro2/repro2	involves: C3HeB/FeJ * C57BL/6J	MGI:3697912

Allelic Composition	repro2/repro2
Genetic Background	involves: C3HeB/FeJ * C57BL/6J

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See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

oligozoospermia ( J:117563 )

• sperm concentration is (0.94 +/- 1.02) x 10⁶ sperm/ml

• however, testes and seminal vesicle weights are similar to wild-type

teratozoospermia ( J:117563 )

• many sperm lack heads and the remainder have abnormal head and/or tail morphology

abnormal sperm fibrous sheath morphology ( J:117563 )

• dysplasia of the fibrous sheath is frequently observed

coiled sperm flagellum ( J:117563 )

• in some cases tail terminate in a coil

short sperm flagellum ( J:117563 )

• sperm frequently display a short tail

abnormal sperm nucleus morphology ( J:117563 )

• abnormal hammerhead nuclear shapes are observed

absent sperm head ( J:117563 )

• many sperm lack heads

abnormal spermatid morphology ( J:117563 )

• some spermatids display abnormal hammerhead nuclear shapes and tail elongation is impaired

immotile sperm ( J:117563 )

• immobile sperm

male infertility ( J:117563 )

impaired fertilization ( J:117563 )

• sperm fail to fertilize oocytes in in vitro fertilization tests

cellular

oligozoospermia ( J:117563 )

• sperm concentration is (0.94 +/- 1.02) x 10⁶ sperm/ml

• however, testes and seminal vesicle weights are similar to wild-type

teratozoospermia ( J:117563 )

• many sperm lack heads and the remainder have abnormal head and/or tail morphology

abnormal sperm fibrous sheath morphology ( J:117563 )

• dysplasia of the fibrous sheath is frequently observed

coiled sperm flagellum ( J:117563 )

• in some cases tail terminate in a coil

short sperm flagellum ( J:117563 )

• sperm frequently display a short tail

abnormal sperm nucleus morphology ( J:117563 )

• abnormal hammerhead nuclear shapes are observed

absent sperm head ( J:117563 )

• many sperm lack heads

abnormal spermatid morphology ( J:117563 )

• some spermatids display abnormal hammerhead nuclear shapes and tail elongation is impaired

immotile sperm ( J:117563 )

• immobile sperm

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