All Phenotypes Map2<repro4> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map2^repro4/Map2^repro4	B6;C3Fe-Map^repro4/J	MGI:3709014
hm2	Map2^repro4/Map2^repro4	C3.B6-Map2^repro4	MGI:5544322

Allelic Composition	Map2^repro4/Map2^repro4
Genetic Background	B6;C3Fe-Map^repro4/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2^repro4 mutation (0 available); any Map2 mutation (109 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal germ cell morphology ( J:92463 )

• some germ cells appear apoptotic

azoospermia ( J:92463 )

• no sperm recovered

arrest of male meiosis ( J:92463 )

• arrest of germ cells during late pachytene stage of meiotic prophase

decreased testis weight ( J:92463 )

• very low testis weight

male infertility ( J:92463 )

endocrine/exocrine glands

decreased testis weight ( J:92463 )

• very low testis weight

cellular

abnormal germ cell morphology ( J:92463 )

• some germ cells appear apoptotic

azoospermia ( J:92463 )

• no sperm recovered

arrest of male meiosis ( J:92463 )

• arrest of germ cells during late pachytene stage of meiotic prophase

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:205107 )

N	• males produce plugs normally in females

decreased testis weight ( J:205107 )

• weight 1/3 that of controls

abnormal spermatogenesis ( J:205107 )

abnormal spermatid morphology ( J:205107 )

• very few round spermatids at 24 days of age

abnormal spermatocyte morphology ( J:205107 )

• increased apoptotic spermatocytes by 17 days of age

arrest of male meiosis ( J:205107 )

• at mid pachytene stage of prophase of meiosis I

• ome spermatocytes do advance

• spermatogonial proliferation is normal however

arrest of spermiogenesis ( J:205107 )

• very few epididymal sperm