All Phenotypes Eif4g3<repro8> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Eif4g3^repro8
reproductive mutant 8, JAX Reproductive Mutagenesis Program
MGI:3512906

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Eif4g3^repro8/Eif4g3^repro8	C3Fe.B6-Eif4g3^repro8/Hand	MGI:6272327
hm2	Eif4g3^repro8/Eif4g3^repro8	involves: C3HeB/FeJ * C57BL/6J	MGI:4443306
ht3	Eif4g3^Gt(XC431)Byg/Eif4g3^repro8	involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J	MGI:4443308

Allelic Composition	Eif4g3^repro8/Eif4g3^repro8
Genetic Background	C3Fe.B6-Eif4g3^repro8/Hand

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif4g3^repro8 mutation (0 available); any Eif4g3 mutation (107 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

arrest of male meiosis ( J:256976 )

• although the mutant protein still localizes normally to the XY body in meiotic prophase spermatocytes, there is meiotic arrest specific to male gametes

cellular

arrest of male meiosis ( J:256976 )

• although the mutant protein still localizes normally to the XY body in meiotic prophase spermatocytes, there is meiotic arrest specific to male gametes

Allelic Composition	Eif4g3^repro8/Eif4g3^repro8
Genetic Background	involves: C3HeB/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif4g3^repro8 mutation (0 available); any Eif4g3 mutation (107 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

azoospermia ( J:159444 )

arrest of male meiosis ( J:159444 )

• in meiotic prophase after mid-pachytene stage

• however, recombination and meiotic chromosome synapsis are normal

increased male germ cell apoptosis ( J:159444 )

• slight at P14 but greater at P17

decreased testis weight ( J:159444 )

• by one third

endocrine/exocrine glands

decreased testis weight ( J:159444 )

• by one third

cellular

azoospermia ( J:159444 )

arrest of male meiosis ( J:159444 )

• in meiotic prophase after mid-pachytene stage

• however, recombination and meiotic chromosome synapsis are normal

increased male germ cell apoptosis ( J:159444 )

• slight at P14 but greater at P17

Allelic Composition	Eif4g3^Gt(XC431)Byg/Eif4g3^repro8
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif4g3^Gt(XC431)Byg mutation (0 available); any Eif4g3 mutation (107 available)
Eif4g3^repro8 mutation (0 available); any Eif4g3 mutation (107 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

azoospermia ( J:159444 )

arrest of male meiosis ( J:159444 )

• no post-meiotic spermatid are produced unlike in wild-type mice

cellular

azoospermia ( J:159444 )

arrest of male meiosis ( J:159444 )

• no post-meiotic spermatid are produced unlike in wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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