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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mybl1repro9
reproductive mutant 9, JAX Reproductive Mutagenesis Program
MGI:3512907
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mybl1repro9/Mybl1repro9 involves: C3HeB/FeJ * C57BL/6J MGI:5292390
ht2
 		Mybl1repro9/Mybl1tm1Epr involves: C3HeB/FeJ * C57BL/6J MGI:5292391


Genotype
MGI:5292390
hm1
Allelic
Composition		 Mybl1repro9/Mybl1repro9
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mybl1repro9 mutation (1 available); any Mybl1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:175539 )
N
• female mice are fertile
• unlike Mybl1tm1Epr homozygotes, mice exhibit normal breast development
azoospermia ( J:175539 )
• mice lack postmeiotic spermatids
arrest of male meiosis ( J:175539 )
• before the mid-pachytene transition
abnormal synaptonemal complex ( J:175539 )
• some spermatocytes fail to establish or maintain synapsis of homologous autosomes

homeostasis/metabolism
abnormal double-strand DNA break repair ( J:175539 )
• spermatocytes exhibit persistent unrepaired double strand breaks and lack crossing over

cellular
azoospermia ( J:175539 )
• mice lack postmeiotic spermatids
arrest of male meiosis ( J:175539 )
• before the mid-pachytene transition
abnormal synaptonemal complex ( J:175539 )
• some spermatocytes fail to establish or maintain synapsis of homologous autosomes
abnormal double-strand DNA break repair ( J:175539 )
• spermatocytes exhibit persistent unrepaired double strand breaks and lack crossing over

growth/size/body
growth/size/body region phenotype ( J:175539 )
N
• unlike Mybl1tm1Epr homozygotes, mice exhibit normal growth

endocrine/exocrine glands




Genotype
MGI:5292391
ht2
Allelic
Composition		 Mybl1repro9/Mybl1tm1Epr
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mybl1repro9 mutation (1 available); any Mybl1 mutation (34 available)
Mybl1tm1Epr mutation (1 available); any Mybl1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
azoospermia ( J:175539 )
• mice lack postmeiotic spermatids
arrest of male meiosis ( J:175539 )
• before the mid-pachytene transition
abnormal synaptonemal complex ( J:175539 )
• some spermatocytes fail to establish or maintain synapsis of homologous autosomes
abnormal testis morphology ( J:175539 )
• some spermatocytes fail to establish or maintain synapsis of homologous autosomes

endocrine/exocrine glands
abnormal testis morphology ( J:175539 )
• some spermatocytes fail to establish or maintain synapsis of homologous autosomes

cellular
azoospermia ( J:175539 )
• mice lack postmeiotic spermatids
arrest of male meiosis ( J:175539 )
• before the mid-pachytene transition
abnormal synaptonemal complex ( J:175539 )
• some spermatocytes fail to establish or maintain synapsis of homologous autosomes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory