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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Akap9repro12
reproductive mutant 12, JAX Reproductive Mutagenesis Program
MGI:3512933
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Akap9repro12/Akap9repro12 involves: C3HeB/FeJ * C57BL/6J MGI:3513136
hm2
 		Akap9repro12/Akap9repro12 involves: C57BL/6J MGI:5516020
ht3
 		Akap9mei2-5/Akap9repro12 involves: 129S1/Sv * C57BL/6J MGI:5516021
ht4
 		Akap9repro12/Akap9tm1b(KOMP)Wtsi involves: C57BL/6J * C57BL/6N * FVB/N MGI:5516022


Genotype
MGI:3513136
hm1
Allelic
Composition		 Akap9repro12/Akap9repro12
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap9repro12 mutation (0 available); any Akap9 mutation (181 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased seminal vesicle weight ( J:92463 )
• low seminal vesicle weight
abnormal seminiferous tubule morphology ( J:92463 )
• few elongated spermatids and abnormal round cells with condensed nuclei in many tubules
decreased testis weight ( J:92463 )
• low testis weight

reproductive system
oligozoospermia ( J:92463 )
• generally no epididymal sperm recovered
globozoospermia ( J:92463 )
• among sperm recovered, there is high frequency of morphological head abnormalities and low IVF success
decreased seminal vesicle weight ( J:92463 )
• low seminal vesicle weight
abnormal seminiferous tubule morphology ( J:92463 )
• few elongated spermatids and abnormal round cells with condensed nuclei in many tubules
decreased testis weight ( J:92463 )
• low testis weight

cellular
oligozoospermia ( J:92463 )
• generally no epididymal sperm recovered
globozoospermia ( J:92463 )
• among sperm recovered, there is high frequency of morphological head abnormalities and low IVF success




Genotype
MGI:5516020
hm2
Allelic
Composition		 Akap9repro12/Akap9repro12
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap9repro12 mutation (0 available); any Akap9 mutation (181 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
arrest of spermatogenesis ( J:198499 )
• germ cells in stage XII tubules do not progress beyond zygonema




Genotype
MGI:5516021
ht3
Allelic
Composition		 Akap9mei2-5/Akap9repro12
Genetic
Background		 involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap9mei2-5 mutation (0 available); any Akap9 mutation (181 available)
Akap9repro12 mutation (0 available); any Akap9 mutation (181 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal spermatogenesis ( J:198499 )
• severely impaired
azoospermia ( J:198499 )
• devoid of mature spermatozoa
arrest of spermatogenesis ( J:198499 )
• no evidence of spermiogenesis
• mice are phenotypically indistinguishable from either single homozygote

cellular
azoospermia ( J:198499 )
• devoid of mature spermatozoa




Genotype
MGI:5516022
ht4
Allelic
Composition		 Akap9repro12/Akap9tm1b(KOMP)Wtsi
Genetic
Background		 involves: C57BL/6J * C57BL/6N * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap9repro12 mutation (0 available); any Akap9 mutation (181 available)
Akap9tm1b(KOMP)Wtsi mutation (0 available); any Akap9 mutation (181 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal spermatogenesis ( J:198499 )
• severely impaired
azoospermia ( J:198499 )
• devoid of mature spermatozoa

cellular
azoospermia ( J:198499 )
• devoid of mature spermatozoa




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory