About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Akap9repro12
reproductive mutant 12, JAX Reproductive Mutagenesis Program
MGI:3512933
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Akap9repro12/Akap9repro12 involves: C3HeB/FeJ * C57BL/6J MGI:3513136
hm2
Akap9repro12/Akap9repro12 involves: C57BL/6J MGI:5516020
ht3
Akap9mei2-5/Akap9repro12 involves: 129S1/Sv * C57BL/6J MGI:5516021
ht4
Akap9repro12/Akap9tm1b(KOMP)Wtsi involves: C57BL/6J * C57BL/6N * FVB/N MGI:5516022


Genotype
MGI:3513136
hm1
Allelic
Composition
Akap9repro12/Akap9repro12
Genetic
Background
involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap9repro12 mutation (0 available); any Akap9 mutation (181 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• low seminal vesicle weight
• few elongated spermatids and abnormal round cells with condensed nuclei in many tubules
• low testis weight

reproductive system
• generally no epididymal sperm recovered
• among sperm recovered, there is high frequency of morphological head abnormalities and low IVF success
• low seminal vesicle weight
• few elongated spermatids and abnormal round cells with condensed nuclei in many tubules
• low testis weight

cellular
• generally no epididymal sperm recovered
• among sperm recovered, there is high frequency of morphological head abnormalities and low IVF success




Genotype
MGI:5516020
hm2
Allelic
Composition
Akap9repro12/Akap9repro12
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap9repro12 mutation (0 available); any Akap9 mutation (181 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• germ cells in stage XII tubules do not progress beyond zygonema




Genotype
MGI:5516021
ht3
Allelic
Composition
Akap9mei2-5/Akap9repro12
Genetic
Background
involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap9mei2-5 mutation (0 available); any Akap9 mutation (181 available)
Akap9repro12 mutation (0 available); any Akap9 mutation (181 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• severely impaired
• devoid of mature spermatozoa
• no evidence of spermiogenesis
• mice are phenotypically indistinguishable from either single homozygote

cellular
• devoid of mature spermatozoa




Genotype
MGI:5516022
ht4
Allelic
Composition
Akap9repro12/Akap9tm1b(KOMP)Wtsi
Genetic
Background
involves: C57BL/6J * C57BL/6N * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap9repro12 mutation (0 available); any Akap9 mutation (181 available)
Akap9tm1b(KOMP)Wtsi mutation (0 available); any Akap9 mutation (181 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• severely impaired
• devoid of mature spermatozoa

cellular
• devoid of mature spermatozoa





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory