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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mad2l2repro22
reproductive mutant 22, JAX Reproductive Mutagenesis Program
MGI:3512941
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mad2l2repro22/Mad2l2repro22 C3.B6(Cg)-Mad2l2repro22 MGI:5584315
hm2
 		Mad2l2repro22/Mad2l2repro22 involves: C3HeB/FeJ * C57BL/6J MGI:3513455


Genotype
MGI:5584315
hm1
Allelic
Composition		 Mad2l2repro22/Mad2l2repro22
Genetic
Background		 C3.B6(Cg)-Mad2l2repro22
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mad2l2repro22 mutation (1 available); any Mad2l2 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, incomplete penetrance ( J:209515 )
• some mice die during embryogenesis

reproductive system
reproductive system phenotype ( J:209515 )
N
• primordial germ cell specification and migration is normal
decreased primordial germ cell number ( J:209515 )
• at E8.5 due to impaired proliferation and/or survival
• however, numbers are normal at E7.25
absent germ cells ( J:209515 )
• absence in male and female mice
small ovary ( J:209515 )
• at 8 weeks
small testis ( J:209515 )
• at 8 weeks
female infertility ( J:209515 )
• however, fertility is restored by expression of a transgene containing the gene
male infertility ( J:209515 )
• however, fertility is restored by expression of a transgene containing the gene

cellular
cellular phenotype ( J:209515 )
N
• spindle assembly checkpoint function is normal in mouse embryonic fibroblasts
decreased primordial germ cell number ( J:209515 )
• at E8.5 due to impaired proliferation and/or survival
• however, numbers are normal at E7.25
absent germ cells ( J:209515 )
• absence in male and female mice
decreased cell proliferation ( J:209515 )
• in mouse embryonic fibroblasts

digestive/alimentary system

growth/size/body
prenatal growth retardation ( J:209515 )
• severe

endocrine/exocrine glands
small ovary ( J:209515 )
• at 8 weeks
small testis ( J:209515 )
• at 8 weeks




Genotype
MGI:3513455
hm2
Allelic
Composition		 Mad2l2repro22/Mad2l2repro22
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mad2l2repro22 mutation (1 available); any Mad2l2 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased oocyte number ( J:92463 )
• no growing oocytes
decreased male germ cell number ( J:92463 )
• obvious germ cell depletion in the testis
azoospermia ( J:92463 )
• no epididymal sperm are recovered
decreased testis weight ( J:92463 )
• low testis weight
arrest of spermatogenesis ( J:92463 )
• spermatogonia are present, but not later spermatogenic stages

endocrine/exocrine glands
decreased testis weight ( J:92463 )
• low testis weight

cellular
decreased oocyte number ( J:92463 )
• no growing oocytes
decreased male germ cell number ( J:92463 )
• obvious germ cell depletion in the testis
azoospermia ( J:92463 )
• no epididymal sperm are recovered




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory