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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tdrd12repro23
reproductive mutant 23, JAX Reproductive Mutagenesis Program
MGI:3512943
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tdrd12repro23/Tdrd12repro23 involves: C3HeB/FeJ * C57BL/6J MGI:3513475


Genotype
MGI:3513475
hm1
Allelic
Composition
Tdrd12repro23/Tdrd12repro23
Genetic
Background
involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tdrd12repro23 mutation (1 available); any Tdrd12 mutation (64 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• no decrease in the number of Leydig cells is detected
• seminiferous tubules contain many germ cells with condensed nuclei probably representing degenerating spermatocytes
• no epididymal sperm recovered (J:92463)
• absence of spermatozoa in the seminiferous tubules (J:166101)
• absence of spermatids in the seminiferous tubules
• low testis weight (J:92463)
• average testes weight is less than 1/3 that of wild-type or heterozygous controls (J:166101)
• arrest of spermatogenesis predominantly at pachytene spermatocyte stage
• slight but significant decrease in weight
(J:92463)
(J:166101)
(J:202012)
• derepression of retrotransposons in germ cells

endocrine/exocrine glands
• low testis weight (J:92463)
• average testes weight is less than 1/3 that of wild-type or heterozygous controls (J:166101)

cellular
• seminiferous tubules contain many germ cells with condensed nuclei probably representing degenerating spermatocytes
• no epididymal sperm recovered (J:92463)
• absence of spermatozoa in the seminiferous tubules (J:166101)
• absence of spermatids in the seminiferous tubules
• arrest of spermatogenesis predominantly at pachytene spermatocyte stage





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory