About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tdrd12repro23
reproductive mutant 23, JAX Reproductive Mutagenesis Program
MGI:3512943
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tdrd12repro23/Tdrd12repro23 involves: C3HeB/FeJ * C57BL/6J MGI:3513475


Genotype
MGI:3513475
hm1
Allelic
Composition		 Tdrd12repro23/Tdrd12repro23
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tdrd12repro23 mutation (1 available); any Tdrd12 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:166101 )
N
• no decrease in the number of Leydig cells is detected
abnormal male germ cell morphology ( J:166101 )
• seminiferous tubules contain many germ cells with condensed nuclei probably representing degenerating spermatocytes
azoospermia ( J:92463 , J:166101 )
• no epididymal sperm recovered (J:92463)
• absence of spermatozoa in the seminiferous tubules (J:166101)
abnormal spermatid morphology ( J:166101 )
• absence of spermatids in the seminiferous tubules
decreased testis weight ( J:92463 , J:166101 )
• low testis weight (J:92463)
• average testes weight is less than 1/3 that of wild-type or heterozygous controls (J:166101)
arrest of male meiosis ( J:92463 )
• arrest of spermatogenesis predominantly at pachytene spermatocyte stage
decreased epididymis weight ( J:166101 )
• slight but significant decrease in weight
male infertility ( J:92463 , J:166101 , J:202012 )
(J:92463)
(J:166101)
(J:202012)
abnormal sperm physiology ( J:202012 )
• derepression of retrotransposons in germ cells

endocrine/exocrine glands
decreased testis weight ( J:92463 , J:166101 )
• low testis weight (J:92463)
• average testes weight is less than 1/3 that of wild-type or heterozygous controls (J:166101)

cellular
abnormal male germ cell morphology ( J:166101 )
• seminiferous tubules contain many germ cells with condensed nuclei probably representing degenerating spermatocytes
azoospermia ( J:92463 , J:166101 )
• no epididymal sperm recovered (J:92463)
• absence of spermatozoa in the seminiferous tubules (J:166101)
abnormal spermatid morphology ( J:166101 )
• absence of spermatids in the seminiferous tubules
arrest of male meiosis ( J:92463 )
• arrest of spermatogenesis predominantly at pachytene spermatocyte stage




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory