hematopoietic system
• circulating platelet count is reduced by about 60%, with megakaryocytes failing to generate abundant proplatelets
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• circulating platelets lacked the characteristic discoid shape and had defective marginal bands with reduced microtubule coilings (2-3 coilings versus 7-12 in wild-type)
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homeostasis/metabolism
• mean bleeding time was 260 seconds compared to 50 seconds in wild-type or heterozygous mice
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