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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tubb1tm1Shiv
targeted mutation 1, Ramesh A Shivdasani
MGI:3513083
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tubb1tm1Shiv/Tubb1tm1Shiv involves: 129/Sv * BALB/c MGI:3514025
hm2
 		Tubb1tm1Shiv/Tubb1tm1Shiv Not Specified MGI:3844967


Genotype
MGI:3514025
hm1
Allelic
Composition		 Tubb1tm1Shiv/Tubb1tm1Shiv
Genetic
Background		 involves: 129/Sv * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tubb1tm1Shiv mutation (0 available); any Tubb1 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thrombocytopenia ( J:94498 )
• circulating platelet count is reduced by about 60%, with megakaryocytes failing to generate abundant proplatelets
abnormal platelet shape ( J:94498 )
• circulating platelets lacked the characteristic discoid shape and had defective marginal bands with reduced microtubule coilings (2-3 coilings versus 7-12 in wild-type)

homeostasis/metabolism
increased bleeding time ( J:94498 )
• mean bleeding time was 260 seconds compared to 50 seconds in wild-type or heterozygous mice




Genotype
MGI:3844967
hm2
Allelic
Composition		 Tubb1tm1Shiv/Tubb1tm1Shiv
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tubb1tm1Shiv mutation (0 available); any Tubb1 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal platelet shape ( J:95293 )
• platelets have a spheroid shape
abnormal platelet physiology ( J:95293 )
• activated platelets have a reduced capacity to inhibit neutrophil elastase activity

homeostasis/metabolism
abnormal platelet physiology ( J:95293 )
• activated platelets have a reduced capacity to inhibit neutrophil elastase activity




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory