mortality/aging
• between E13 and E15, 52% of mice are dead
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• no mice are present at 3 weeks of age
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Allele Symbol Allele Name Allele ID |
Erbb3tm1.1Dwt targeted mutation 1.1, David Threadgill MGI:3513098 |
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Summary |
5 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• between E13 and E15, 52% of mice are dead
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• no mice are present at 3 weeks of age
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• unlike ApcMin heterozygotes, mice do not develop colonic polyps
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• mice develop fewer intestinal polyps compared to in ApcMin heterozygotes
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• the number and size of microadenomas in the intestine are decreased compared to in ApcMin heterozygotes due to an increased in Caspase-3 dependent apoptosis
• mice fail to develop colon tumors unlike ApcMin heterozygotes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• no mice were detected (no time of death given)
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• following treatment with DSS, mice exhibit greater weight loss than similarly treated control mice and mild lesions with loss of mucus cells, glandular hyperplasia, and increased leukocyte levels in the lamina propria to severe lesions with complete loss of glandular epithelium, followed by collapse of denuded lamina propria, submucosal edema, fibrinoid necrosis of lamina propria vessels, and infiltration of neutrophils and plasma cells
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• following treatment with DSS, mice exhibit greater weight loss than similarly treated control mice and mild lesions with loss of mucus cells, glandular hyperplasia, and increased leukocyte levels in the lamina propria to severe lesions with complete loss of glandular epithelium, followed by collapse of denuded lamina propria, submucosal edema, fibrinoid necrosis of lamina propria vessels, and infiltration of neutrophils and plasma cells
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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