Phenotypes associated with this allele

• Allele Symbol: Tgfb1^tm1Jmu
• Allele Name: targeted mutation 1, John Munger
• Allele ID: MGI:3513111
• Summary: 10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tgfb1^tm1Jmu/Tgfb1^tm1Jmu	involves: 129 * C57BL/6J * ICR * Swiss Webster	MGI:5008414
hm2	Tgfb1^tm1Jmu/Tgfb1^tm1Jmu	involves: 129S6/SvEvTac * C57BL/6	MGI:3717768
hm3	Tgfb1^tm1Jmu/Tgfb1^tm1Jmu	involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster	MGI:3717770
ht4	Tgfb1^tm1Jmu/Tgfb1^+	involves: 129S6/SvEvTac * C57BL/6	MGI:3717769
cx5	Tgfb1^tm1Jmu/Tgfb1^tm1Jmu Tgfb3^tm1Doe/Tgfb3^tm1Doe	involves: 129 * BALB/c * C57BL/6J * Swiss Webster	MGI:5008412
cx6	Tgfb1^tm1Jmu/Tgfb1^tm1Jmu Tgfb3^tm1Doe/Tgfb3^+	involves: 129 * BALB/c * C57BL/6J * Swiss Webster	MGI:5008410
cx7	Tgfb1^tm1Jmu/Tgfb1^tm1Jmu Tgfb3^tm1Doe/Tgfb3^tm1Doe	involves: 129 * C57BL/6J * ICR * Swiss Webster	MGI:5008415
cx8	Tgfb1^tm1Jmu/Tgfb1^tm1Jmu Tgfb3^tm1Doe/Tgfb3^+	involves: 129 * C57BL/6J * ICR * Swiss Webster	MGI:5008413
cx9	Tgfb1^tm1Jmu/Tgfb1^tm1Jmu Tgfb3^tm1Doe/Tgfb3^tm1Doe	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * Swiss Webster	MGI:5008411
cx10	Tgfb1^tm1Jmu/Tgfb1^tm1Jmu Tgfb3^tm1Doe/Tgfb3^+	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * Swiss Webster	MGI:5008408

Genotype
MGI:5008414

hm1

• Allelic Composition: Tgfb1^tm1Jmu/Tgfb1^tm1Jmu
• Genetic Background: involves: 129 * C57BL/6J * ICR * Swiss Webster

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

intracranial hemorrhage ( J:136106 )

• very mild in some mice

nervous system

intracranial hemorrhage ( J:136106 )

• very mild in some mice

Genotype
MGI:3717768

hm2

• Allelic Composition: Tgfb1^tm1Jmu/Tgfb1^tm1Jmu
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Tgfb1^tm1Jmu/Tgfb1^tm1Jmu mice develop fatal multiorgan inflammation

mortality/aging

postnatal lethality ( J:120085 )

• mice have reduced survival

prenatal lethality, incomplete penetrance ( J:120085 )

• while Mendelian ratios are present at E10.5, fewer than expected pups are born

immune system

absent Langerhans cell ( J:120085 )

abnormal immune system physiology ( J:120085 )

• between 18 and 28 days, marked mononuclear cell infiltration of multiple tissues, in particular, the heart, lung, liver, stomach, and pancreas and occasionally the central nervous system

heart inflammation ( J:120085 )

stomach inflammation ( J:120085 )

pancreas inflammation ( J:120085 )

liver inflammation ( J:120085 )

• inflammation lesions in the liver are localized to the portal canal

lung inflammation ( J:120085 )

• in the lung, inflammatory lesions are usually localized to bronchi and larger vessels and sometimes diffusely within the alveolar walls

embryo

absent vitelline blood vessels ( J:120085 )

• at E10.5, yolk sacs lack normal vasculature

• at E12.5, yolk sac vasculature is not identifiable

abnormal visceral yolk sac morphology ( J:120085 )

• at E10.5, yolk sacs have a variable paucity of vessels, absence of hemotopoietic cells and extensive buckling between the mesodermal and endodermal layer

excessive folding of visceral yolk sac ( J:120085 )

• at E10.5, yolk sacs have extensive buckling between the mesodermal and endodermal layer

pale yolk sac ( J:120085 )

• at E10.5, yolk sacs are anemic or lacking normal vasculature

growth/size/body

decreased body size ( J:120085 )

• at day 14, mice are smaller in size

liver/biliary system

liver inflammation ( J:120085 )

• inflammation lesions in the liver are localized to the portal canal

respiratory system

lung inflammation ( J:120085 )

• in the lung, inflammatory lesions are usually localized to bronchi and larger vessels and sometimes diffusely within the alveolar walls

hematopoietic system

absent Langerhans cell ( J:120085 )

cardiovascular system

absent vitelline blood vessels ( J:120085 )

• at E10.5, yolk sacs lack normal vasculature

• at E12.5, yolk sac vasculature is not identifiable

heart inflammation ( J:120085 )

digestive/alimentary system

stomach inflammation ( J:120085 )

endocrine/exocrine glands

pancreas inflammation ( J:120085 )

Genotype
MGI:3717770

hm3

• Allelic Composition: Tgfb1^tm1Jmu/Tgfb1^tm1Jmu
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster

mortality/aging

postnatal lethality, incomplete penetrance ( J:120085 )

• phenotype is indistinguishable from that seen on a 129S6/SvEvTac C57BL/6 background

prenatal lethality, incomplete penetrance ( J:120085 )

• phenotype is indistinguishable from that seen on a 129S6/SvEvTac C57BL/6 background

immune system

absent Langerhans cell ( J:120085 )

abnormal immune system physiology ( J:120085 )

• phenotype is indistinguishable from that seen on a 129S6/SvEvTac C57BL/6 background

embryo

abnormal extraembryonic tissue morphology ( J:120085 )

• phenotype is indistinguishable from that seen on a 129S6/SvEvTac C57BL/6 background

liver/biliary system

abnormal liver morphology ( J:120085 )

• phenotype is indistinguishable from that seen on a 129S6/SvEvTac C57BL/6 background

respiratory system

abnormal lung morphology ( J:120085 )

• phenotype is indistinguishable from that seen on a 129S6/SvEvTac C57BL/6 background

hematopoietic system

absent Langerhans cell ( J:120085 )

Genotype
MGI:3717769

ht4

• Allelic Composition: Tgfb1^tm1Jmu/Tgfb1⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

mortality/aging

prenatal lethality, incomplete penetrance ( J:120085 )

• while Mendelian ratios are present at E10.5, fewer than expected pups are born

Genotype
MGI:5008412

cx5

• Allelic Composition: Tgfb1^tm1Jmu/Tgfb1^tm1Jmu; Tgfb3^tm1Doe/Tgfb3^tm1Doe
• Genetic Background: involves: 129 * BALB/c * C57BL/6J * Swiss Webster

mortality/aging

prenatal lethality, incomplete penetrance ( J:136106 )

• very few mice are born

• Background Sensitivity: fewer mice are born than on a background lacking BALB/c or containing ICR

cardiovascular system

intracranial hemorrhage ( J:136106 )

• in all mice

nervous system

intracranial hemorrhage ( J:136106 )

• in all mice

Genotype
MGI:5008410

cx6

• Allelic Composition: Tgfb1^tm1Jmu/Tgfb1^tm1Jmu; Tgfb3^tm1Doe/Tgfb3⁺
• Genetic Background: involves: 129 * BALB/c * C57BL/6J * Swiss Webster

mortality/aging

postnatal lethality, incomplete penetrance ( J:136106 )

• most mice only survive 3 weeks before dying of widespread inflammation

cardiovascular system

intracranial hemorrhage ( J:136106 )

• rarely

nervous system

intracranial hemorrhage ( J:136106 )

• rarely

Genotype
MGI:5008415

cx7

• Allelic Composition: Tgfb1^tm1Jmu/Tgfb1^tm1Jmu; Tgfb3^tm1Doe/Tgfb3^tm1Doe
• Genetic Background: involves: 129 * C57BL/6J * ICR * Swiss Webster

mortality/aging

mortality/aging ( J:136106 )

N • Background Sensitivity: more mice are born on a background containing ICR than on a background containing BALB/c or lacking both ICR and BALB/c

neonatal lethality, complete penetrance ( J:136106 )

• all mice die within hours of birth

nervous system

abnormal brain vasculature morphology ( J:136106 )

• as early as E11.5

• at E13.5, brain vasculature exhibits extensive cavitation compared to in control mice

• in newborn mice, brain vessels are enlarged and hyperplastic compared to in control mice

intracranial hemorrhage ( J:136106 )

• as early as E11.5

• severe by E15.5

• in all mice

hydrocephaly ( J:136106 )

• associated with brain hemorrhage

enlarged brain ventricles ( J:136106 )

• enlarged ventricles

cardiovascular system

abnormal brain vasculature morphology ( J:136106 )

• as early as E11.5

• at E13.5, brain vasculature exhibits extensive cavitation compared to in control mice

• in newborn mice, brain vessels are enlarged and hyperplastic compared to in control mice

intracranial hemorrhage ( J:136106 )

• as early as E11.5

• severe by E15.5

• in all mice

craniofacial

cleft secondary palate ( J:136106 )

• more extensive complete cleft of the secondary palate compared to in Tgfb3^tm1Doe homozygotes on the same background

respiratory system

respiratory system phenotype ( J:136106 )

N • mice exhibit normal lung morphology

digestive/alimentary system

cleft secondary palate ( J:136106 )

• more extensive complete cleft of the secondary palate compared to in Tgfb3^tm1Doe homozygotes on the same background

growth/size/body

cleft secondary palate ( J:136106 )

• more extensive complete cleft of the secondary palate compared to in Tgfb3^tm1Doe homozygotes on the same background

Genotype
MGI:5008413

cx8

• Allelic Composition: Tgfb1^tm1Jmu/Tgfb1^tm1Jmu; Tgfb3^tm1Doe/Tgfb3⁺
• Genetic Background: involves: 129 * C57BL/6J * ICR * Swiss Webster

mortality/aging

postnatal lethality, incomplete penetrance ( J:136106 )

• most mice only survive 3 weeks before dying of widespread inflammation

cardiovascular system

abnormal brain vasculature morphology ( J:136106 )

• in newborn mice, brain vasculature exhibits cavitation compared to in control mice

intracranial hemorrhage ( J:136106 )

• in all newborn mice

• less severe than in double homozygotes

nervous system

abnormal brain vasculature morphology ( J:136106 )

• in newborn mice, brain vasculature exhibits cavitation compared to in control mice

intracranial hemorrhage ( J:136106 )

• in all newborn mice

• less severe than in double homozygotes

hydrocephaly ( J:136106 )

• in newborn mice

Genotype
MGI:5008411

cx9

• Allelic Composition: Tgfb1^tm1Jmu/Tgfb1^tm1Jmu; Tgfb3^tm1Doe/Tgfb3^tm1Doe
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * Swiss Webster

mortality/aging

prenatal lethality, incomplete penetrance ( J:136106 )

• very few mice are born

• Background Sensitivity: more mice are born than on a background lacking BALB/c, but fewer mice are born than on a background containing ICR

embryonic lethality during organogenesis, incomplete penetrance ( J:136106 )

• most mice die between E8.5 and E12.5

cardiovascular system

absent vitelline blood vessels ( J:136106 )

• in non-viable mice

intracranial hemorrhage ( J:136106 )

• in all mice

embryo

absent vitelline blood vessels ( J:136106 )

• in non-viable mice

nervous system

intracranial hemorrhage ( J:136106 )

• in all mice

Genotype
MGI:5008408

cx10

• Allelic Composition: Tgfb1^tm1Jmu/Tgfb1^tm1Jmu; Tgfb3^tm1Doe/Tgfb3⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * Swiss Webster

mortality/aging

postnatal lethality, incomplete penetrance ( J:136106 )

• most mice only survive 3 weeks before dying of widespread inflammation

embryonic lethality during organogenesis, incomplete penetrance ( J:136106 )

• most mice die between E8.5 and E12.5

cardiovascular system

absent vitelline blood vessels ( J:136106 )

• in non-viable mice

intracranial hemorrhage ( J:136106 )

• rarely

embryo

absent vitelline blood vessels ( J:136106 )

• in non-viable mice

nervous system

intracranial hemorrhage ( J:136106 )

• rarely