Phenotypes associated with this allele

• Allele Symbol: Klf11^tm1Czs
• Allele Name: targeted mutation 1, Chao-Zhong Song
• Allele ID: MGI:3513147
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klf11^tm1Czs/Klf11^tm1Czs	B6.129-Klf11^tm1Czs	MGI:6272000
hm2	Klf11^tm1Czs/Klf11^tm1Czs	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3513325

Genotype
MGI:6272000

hm1

• Allelic Composition: Klf11^tm1Czs/Klf11^tm1Czs
• Genetic Background: B6.129-Klf11^tm1Czs

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased susceptibility to injury ( J:200159 )

♀ • females in which endometriosis is surgically induced show larger peritoneal lesions with prolific fibrosis compared to controls, resembling advanced human endometriosis

reproductive system

uterus adenomyosis ( J:200159 )

♀ • females in which endometriosis is surgically induced show larger peritoneal lesions with prolific fibrosis compared to controls, resembling advanced human endometriosis

♀ • lesions in endometriosis-induced females are cystic in contrast to small, involuting lesions in controls and are associated with extensive, dense adhesions involving the small intestine, colon, stomach, and liver

Genotype
MGI:3513325

hm2

• Allelic Composition: Klf11^tm1Czs/Klf11^tm1Czs
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

neoplasm

neoplasm ( J:94499 )

N • no increase in tumor formation after gamma-irradiation was observed indicating that it is not necessary for tumor suppression

hematopoietic system

hematopoietic system phenotype ( J:94499 )

N • hematopoiesis at all stages of development was normal

normal phenotype

no abnormal phenotype detected ( J:94499 )

• mice are fertile, grow normally and live as long as wild-type without evident pathological defects